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Key Lipoprotein Receptor Targeted Echinacoside-Liposomes Effective Against Parkinson's Disease in Mice Model.
Int J Nanomedicine
August 2024
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, People's Republic of China.
Article Synopsis
- Parkinson's disease is a neurodegenerative disorder marked by the loss of dopamine-producing neurons, with no effective treatments currently available.
- Echinacoside (ECH) has neuroprotective properties, but its effectiveness is limited by the blood-brain barrier, which makes it difficult for the drug to reach the brain effectively.
- Researchers developed PEGylated ECH liposomes modified with a targeting peptide (ECH@ANG-Lip), which showed improved brain uptake and greater protection against neurodegeneration compared to other formulations in a lab model of Parkinson's disease.
Selective Neurectomy for Postfacial Paralysis Synkinesis: A Systematic Review.
Facial Plast Surg
August 2024
Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, Ontario, Canada.
Facial synkinesis is characterized by unintentional contractions of facial musculature secondary to aberrant facial nerve healing. The associated impairment in facial functioning results in a significant decrease in patients' quality of life. The mainstay treatment for postfacial paralysis synkinesis (PFPS) is chemodenervation and physiotherapy, which requires long-term maintenance neurotoxin injections.
View Article and Find Full Text PDFWhy do marionette lines appear? Exploring the anatomical perspectives and role of thread-based interventions.
Skin Res Technol
April 2024
Division in Anatomy and Developmental Biology, Department of Oral Biology, Human Identification Research Institute, BK21 FOUR Project, Yonsei University College of Dentistry, Seoul, South Korea.
The pathogenesis of marionette lines involves a complex interplay of anatomical, physiological, and age-related factors leading to the development of wrinkles around the oral commissures. This exploration delves into the distinct anatomical predispositions observed among different ethnicities, emphasizing the role of compact modiolus structures and muscle compositions. Notably, individuals of East Asian descent exhibit inherent facial structures that predispose them to pronounced sagging around the oral commissures during aging.
View Article and Find Full Text PDFIn-vivo assessment of application of folinic acid and botulinum toxin A in cleft lip surgical defects.
Orthod Craniofac Res
June 2024
Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples "Federico II", Naples, Italy.
Introduction: Folinic acid and botulinum toxin A have shown promising results in wound healing in different studies. This study aimed to compare the effects of these approaches on wound healing after simulating cleft lip surgery in rats.
Methods: In this experimental animal study, after creating lip defects, 30 rats were randomly divided into three groups and received normal saline (CTL), botulinum toxin A (BOT), and folinic acid (FOL).
Selective Myectomies Alone versus Selective Myectomies Combined with Neurectomies in Postparetic Synkinesis: Comparing Outcomes.
Plast Reconstr Surg
October 2024
From the Department of Plastic Surgery, University of Texas Southwestern Medical Center.
Background: In postparetic synkinesis, muscle tone imbalance between upper and lower lip depressors and elevators results in the inability to produce an effective smile. Surgical treatments to improve smile focus on restoring tonicity balance between perioral muscles by weakening hypertoned muscles through selective myectomies or selective neurectomies. The goal of this study was to compare objective outcomes between selective myectomies alone with those of selective myectomies combined with selective neurectomies.
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