Introduction: There is some evidence regarding the role of LAG-3, TLR mediated neuroinflammation in PD.
Methods: sLAG-3, TOLLIP, NLRP3 levels were measured in PD and healthy controls.
Results: These markers were significantly higher in PD and were associated with progression.
Conclusion: sLAG3 and TOLLIP are involved in the NLRP3 mediated inflammatory activation in PD.
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http://dx.doi.org/10.1016/j.parkreldis.2021.09.019 | DOI Listing |
Immunol Res
December 2024
Department of Immunology, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey.
Natural killer (NK) cells are a cytotoxic subset of innate lymphoid cells and have key roles in antitumoral immunity. This study evaluates the roles of immune checkpoint receptors on NK cell phenotype and functions both before and after circulation through tumor tissue. Twenty non-small cell lung cancer patients undergoing surgery and 21 healthy controls were included.
View Article and Find Full Text PDFOpen Forum Infect Dis
November 2024
Department of Internal Medicine, Division of Infectious Diseases, University of Texas Medical Branch, Galveston, Texas, USA.
Background: Co-inhibitory receptors (immune checkpoints) regulate activated immune cells. Their expression on T cells can limit host defense. We hypothesized that chronic infection in patients with visceral leishmaniasis (VL) leads to expression of co-inhibitory receptors that could be markers of treatment response and clinical outcome.
View Article and Find Full Text PDFJ Clin Exp Hepatol
October 2024
Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.
Background: Alcohol-associated hepatitis (AH) has a short-term mortality rate of up to 40% primarily related to impaired hepatocyte regeneration and uncontrolled liver inflammation. The acute phase protein fibrinogen-like protein 1 (FGL-1) produced by hepatocytes stimulates hepatocyte proliferation by autocrine signaling. FGL-1 also is a ligand for the inhibitory T cell receptor lymphocyte activation gene 3 (LAG-3).
View Article and Find Full Text PDFJ Clin Endocrinol Metab
October 2024
Department of Endocrinology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Context: Soluble immune checkpoints play an important role in peripheral tolerance that has seldom been investigated in Graves' disease (GD) and thyroid eye disease (TED).
Objective: The objective of this work is to examine the alteration of soluble immune checkpoints in GD and TED.
Methods: We performed a quantitative multiplex analysis of 17 immune checkpoint proteins in serum from 50 GD patients without TED, 28 GD patients with TED and 40 healthy controls.
JTO Clin Res Rep
November 2024
Research and Development, Immutep S.A.S., Saint-Aubin, France.
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