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Adding Dexmedetomidine to Methylene Blue in Thoracic Paravertebral Block for Video-Assisted Lobectomy: A Case Series Study.
Local Reg Anesth
December 2024
Department of Women, Children and General and Specialized Surgery, University of Campania Luigi Vanvitelli, Naples, Italy.
Article Synopsis
- This study evaluates the effectiveness of adding dexmedetomidine (DEX) to Thoracic Paravertebral Block (TPVB) for managing postoperative pain in patients undergoing thoracic surgery.
- Six patients were monitored after receiving TPVB with ropivacaine, DEX, and methylene blue, focusing on pain levels and opioid use in the first 48 hours post-surgery.
- Results indicated that patients experienced low pain scores and reduced opioid consumption without significant side effects, suggesting DEX enhances the effectiveness of TPVB while methylene blue aids in ensuring proper anesthetic distribution.
Compact Arterial Monitoring Device Use in Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA): A Simple Validation Study in Swine.
Cureus
October 2024
Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, USA.
Article Synopsis
- - Hemorrhage is the main cause of preventable death in trauma situations, leading to military and civilian advancements in medical practices, particularly through the use of tourniquets to manage extremity bleeding and save lives.
- - While tourniquets have significantly decreased deaths from bleeding in military settings, noncompressible hemorrhage still poses a major risk, especially before patients receive definitive medical care.
- - The study explores using a small, disposable pressure monitor during resuscitative endovascular balloon occlusion of the aorta (REBOA) to enhance blood pressure monitoring, facilitate better resuscitation practices, and reduce the need for blood products in extreme environments.
Impact of Duration of Adjuvant Therapy on Patients with Initially Unresectable Hepatocellular Carcinoma After Conversion Surgery: A Propensity Score Matching Study.
J Hepatocell Carcinoma
September 2024
The Shengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian Province, People's Republic of China.
Background: This study aimed to assess the effect of adjuvant therapy with different durations in patients with initially unresectable hepatocellular carcinoma (uHCC) after conversion surgery.
Methods: This study included 85 patients with initially uHCC who received conversion surgery between May 2019 and November 2022. They were divided into the long duration group (n = 57) and short duration group (n = 28) based on postoperative medication duration.
Background: The recently approved AS01E-adjuvanted respiratory syncytial virus (RSV) prefusion F protein-based vaccine for older adults (RSVPreF3 OA) demonstrated high efficacy against RSV-related disease in ≥60-year-olds.
Methods: This ongoing phase 3 study in ≥60-year-olds evaluates immune persistence until 3 years after RSVPreF3 OA vaccination. Here, we describe interim results on humoral and cell-mediated immunogenicity, reactogenicity, and safety until 1 year post-dose 1.
Opioid-free general anesthesia: considerations, techniques, and limitations.
Curr Opin Anaesthesiol
August 2024
Department of Anesthesiology & Pain Management, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Purpose Of Review: To discuss the role of opioids during general anesthesia and examine their advantages and risks in the context of clinical practice. We define opioid-free anesthesia (OFA) as the absolute avoidance of intraoperative opioids.
Recent Findings: In most minimally invasive and short-duration procedures, nonopioid analgesics, analgesic adjuvants, and local/regional analgesia can significantly spare the amount of intraoperative opioid needed.
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