Association between serum alanine and aspartate aminotransferase and blood pressure: a cross-sectional study of Chinese freshmen.

BMC Cardiovasc Disord

Department of Epidemiology and Biostatistics, School of Public Health, Wannan Medical College, No. 22, Wenchang Road, Wuhu, 241002, Anhui, China.

Published: October 2021

Background: High blood pressure is a well-recognized risk factor for cardiovascular events, and the incidence of hypertension is increasing among young people. This study investigated the relationship between ALT and AST levels and hypertension among freshmen in China.

Methods: This cross-sectional study was conducted in the Anhui Province from September to November 2018. A total of 3114 freshmen underwent a physical examination including testing of biochemical indicators and a standardized questionnaire.

Results: The overall prevalence of elevated ALT and AST were 6.8% and 2.3% among freshmen. The mean ALT and AST levels were higher in males (22.59 ± 21.98 vs.12.62 ± 10.30 U/L; 23.55 ± 12.24 vs. 20.02 ± 5.75 U/L, respectively). The prevalence of hypertension was significantly higher in men (16.1%) than in women (1.9%). The mean values of BMI, SBP, DBP, TC, TG, and LDL-C were found to be increased with elevated levels of serum ALT and AST in the quartiles (P for trend < 0.05). After adjusting for covariates, the risk of hypertension was significantly higher in the highest ALT quartile than in the lowest quartile (OR (95% CI) of 1.681 (1.028, 2.751) in males; 2.802 (1.102, 7.124) in females). A strong linear relationship was found between serum ALT levels and the odds of hypertension after adjustment for potential confounders only in total population and females (P for trend < 0.05).

Conclusions: These findings suggest that ALT level is significantly associated with hypertension both in male and female freshmen.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8485510PMC
http://dx.doi.org/10.1186/s12872-021-02282-1DOI Listing

Publication Analysis

Top Keywords

alt ast
16
blood pressure
8
cross-sectional study
8
ast levels
8
association serum
4
serum alanine
4
alanine aspartate
4
aspartate aminotransferase
4
aminotransferase blood
4
pressure cross-sectional
4

Similar Publications

Perfusion Pressures and Weight Loss During Normothermic Machine Perfusion of Human Donor Livers.

Artif Organs

December 2024

Department of Surgery, Section of Hepatobiliary Surgery and Liver Transplantation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Background: Normothermic machine perfusion (NMP) is increasingly used to preserve and assess donor livers prior to transplantation. Due to its success, it is expected that more centers will start using this technology. However, NMP may also cause adverse effects.

View Article and Find Full Text PDF

Background: Mycotoxins are considered one of the most important problems and threats that face poultry producers.

Aim: This study was conducted to investigate the pathological, hematological, and biochemical alterations in chickens fed on mycotoxins contamination ration.

Methods: 434 feed samples were collected from poultry farms operating in Babil Governorate/Iraq, where feed samples were collected over the course of 2023, and these samples were tested by direct competitive enzyme-linked immunosorbent assay to determine the level of mycotoxins.

View Article and Find Full Text PDF

Methyl donors regulate the one-carbon metabolism and have significant potential to reduce oxidative stress and inflammation. Therefore, this study aims to investigate the protective effect of methyl donors against CCl-induced liver fibrosis. Liver fibrosis was induced in male Sprague Dawley rats using CCl at a dose of 1ml/kg (twice a week for a 4-week, via intraperitoneal route).

View Article and Find Full Text PDF

Ethnopharmacological Relevance: Epimedium Tourn. ex L. is a traditional Chinese medicine used for thousands of years in China to treat forgetfulness.

View Article and Find Full Text PDF

Sulfonamide-Pyrazole derivatives as next-generation Cyclooxygenase-2 enzyme inhibitors: From molecular design to in vivo efficacy.

Int J Biol Macromol

December 2024

Applied Organic Chemistry Department, National Research Center, Dokki, Cairo 12622, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Pharos University in Alexandria, Canal El Mahmoudia St., Alexandria 21648, Egypt. Electronic address:

The current research focuses on the design and synthesis of celecoxib analogues incorporating sulphonamide pyrazole moieties 4, 5, 6a-e, and 7a-f with the aim of achieving a broad range of COX-2 selectivity in vitro. Among these, compounds 6b-d, 7a, 7e, and 7d exhibited potent inhibition, with IC values ranging between 0.05 and 0.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!