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Chorionic gonadotropin stimulates maternal hepatocyte proliferation during pregnancy. | LitMetric

Chorionic gonadotropin stimulates maternal hepatocyte proliferation during pregnancy.

Biochem Biophys Res Commun

Department of Chemical Biology, National Center for Geriatrics and Gerontology, Obu, Aichi, 474-8511, Japan. Electronic address:

Published: November 2021

AI Article Synopsis

Article Abstract

The liver increases its size during pregnancy to adapt to metabolic demand associated with pregnancy. Our previous study showed that proliferation of maternal hepatocytes are increased during pregnancy in mice and that estradiol (E2) is one of the candidate hormones responsible for maternal hepatocyte proliferation. Here, we discovered that chorionic gonadotropin (CG) induces maternal hepatocyte proliferation during pregnancy. CG administration was sufficient to stimulate hepatocyte proliferation in non-pregnant mice as well as in cell culture system. We conclude that CG stimulates proliferation in the early pregnancy of maternal hepatocytes. In contrast, estrogen stimulates hepatocyte proliferation in the late pregnancy.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568302PMC
http://dx.doi.org/10.1016/j.bbrc.2021.09.039DOI Listing

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