Context Despite the considerable resources devoted and the efforts of the many actors involved, the gap between the production of scientific knowledge and its use in practice remains a challenge. The use of information and communication technologies (ICTs) is a valuable tool for reducing this gap. To address this challenge, a demonstration project focusing on the use of technology for knowledge translation was implemented with 23 community support teams in 5 regions of Quebec (2016-2018). More than 324 mental health professionals, team leaders and managers have benefited from the initiative "At your fingertips, best recovery-oriented practices." Objective This article presents the results of a satisfaction survey of team leaders responsible for clinical support in the community support teams under study. The purpose of this study is to enhance the understanding of issues identified during implementation and to make recommendations for the sustainable scaling up of the implemented knowledge translation program. Method A qualitative design in this evaluative research was adopted. At the end of the program implementation process, 2 group interviews were conducted with the team leaders. A content analysis following an inductive approach with 3 levels of coding was performed. Results The results show a significant digital gap within the Quebec health and social services network compared to other sectors of activity. Participants underlined the importance of adopting mechanisms for knowledge exchange and transfer that are integrated into organizational practices (dedicated time, formal clinical supervision, etc.) and which make use of ICTs. Conclusion Despite the significant technology upgrade required, the results suggest the relevance of using techno-pedagogy as the primary means of supporting knowledge translation and practice transformation. The tools developed and the support mechanisms explored appear to facilitate access to and adoption of best practices in mental health.
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Kardiol Pol
January 2025
Non-Profit Research Association Alliance for the Promotion of Preventive Medicine, Mechelen, Belgium.
Epilepsia
January 2025
Applied Translational Neurogenomics Group, Vlaams Instituut voor Biotechnology (VIB) Center for Molecular Neurology, VIB, Antwerp, Belgium.
Objective: This study aims to improve genetic diagnosis in childhood onset epilepsy with neurodevelopmental problems by utilizing RNA sequencing of fibroblasts to identify pathogenic variants that may be missed by exome sequencing and copy number variation analysis.
Methods: We enrolled 41 individuals with childhood onset epilepsy and neurodevelopmental problems who previously had inconclusive genetic testing. Fibroblast samples were cultured and analyzed using RNA sequencing to detect aberrant expression, aberrant splicing, and monoallelic expression using the Detection of RNA Outlier Pipeline (DROP) pipeline.
J Mater Chem B
January 2025
Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, Laboratory of Advanced Theranostic Materials and Technology, Chinese Academy of Sciences (CAS) Key Laboratory of Magnetic Materials and Devices, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China.
The critical need for rapid cancer diagnosis and related illnesses is growing alongside the current healthcare challenges, unfavorable prognosis, and constraints in diagnostic timing. As a result, emphasis on surface-enhanced Raman spectroscopy (SERS) diagnostic methods, including both label-free and labelled approaches, holds significant promise in fields such as analytical chemistry, biomedical science, and physics, due to the user-friendly nature of SERS. Over time, the SERS detection sensitivity and specificity with nanostructured materials for SERS applications (NMs-SERS) in different media have been remarkable.
View Article and Find Full Text PDFImmunol Rev
March 2025
Graduate Program in Translational Biology, Medicine, and Health, Virginia Tech, Roanoke, Virginia, USA.
A robust innate immune response is essential in combating viral pathogens. However, it is equally critical to quell overzealous immune signaling to limit collateral damage and enable inflammation resolution. Pattern recognition receptors are critical regulators of these processes.
View Article and Find Full Text PDFBJUI Compass
January 2025
OncoAssure Ltd, NovaUCD Dublin Ireland.
Objectives: This study aimed to clinically validate the six-gene prognostic molecular clinical risk score (MCRS) for the prediction of aggressive prostate cancer in diagnostic biopsy tissue.
Methods: MCRS was evaluated in prostate biopsy tissue from a Swedish cohort of men with prostate cancer (UPCA, = 100). The primary outcome of adverse pathology and secondary outcomes of high primary Gleason (≥G4) and high pathological T-stage (≥T3) were assessed by likelihood ratio statistics and area under the receiver operating characteristic curves from logistic regression models; time to biochemical recurrence was assessed by likelihood ratio statistics and C-indexes from Cox proportional hazard regression models.
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