Background: Years of life lost (YLL) is a meaningful indicator of the relevance of causes of death, although it is rarely used in Germany. Numerous methods have been developed to calculate YLL.
Objective: Prototypical methods for calculating YLL are presented and critically appraised. An improved method is proposed that is based on cause-elimination life tables (CELTs).
Methods: The different methods are applied to deaths in Germany in 2018. Changes in comparison to 1998 are presented using the modified method.
Results: While in 2018 cardiovascular diseases were the leading cause of death by number of cases, cancer was responsible for most YLL. Different methods of calculating YLL lead to divergent ranks for less frequent causes of death. YLL on the basis of general life tables underestimate CELT-based YLL by up to 18.4% (cardiovascular diseases). Measured by CELT-based YLL, cardiovascular diseases were the most important cause of death in 1998.
Conclusion: The calculation of YLL on the basis of CELTs avoids inconsistencies of established methods and leads to relevantly different results. Characteristics of the proposed method (violation of the egalitarian principle, lack of additivity) do not affect its usefulness as a tool for health planning.
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http://dx.doi.org/10.1007/s00103-021-03424-8 | DOI Listing |
Biol Direct
January 2025
National Key Laboratory for Innovation and Transformation of Luobing Theory; The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, Jinan, China.
Background: Carotid atherosclerotic plaque is the primary cause of cardiovascular and cerebrovascular diseases. It is closely related to oxidative stress and immune inflammation. This bioinformatic study was conducted to identify key oxidative stress-related genes and key immune cell infiltration involved in the formation, progression, and stabilization of plaques and investigate the relationship between them.
View Article and Find Full Text PDFTrials
January 2025
Université Côte d'Azur, CNRS, LP2M, Nice, France.
Background: /aims. Pseudoxanthoma Elasticum (PXE, OMIM 264800) is an autosomal, recessive, metabolic disorder characterized by progressive ectopic calcification in the skin, the vasculature and Bruch's membrane. Variants in the ABCC6 gene are associated with low plasma pyrophosphate (PPi) concentration.
View Article and Find Full Text PDFCrit Care
January 2025
Department of Intensive Care Unit, The First Hospital of China Medical University, Shenyang, China.
Background: The role that sleep patterns play in sepsis risk remains poorly understood.
Objectives: The objective was to evaluate the association between various sleep behaviours and the incidence of sepsis.
Methods: In this prospective cohort study, we analysed data from the UK Biobank (UKB).
Cardiovasc Diabetol
January 2025
Department of Cardiology, the First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan 2nd Road, Guangzhou, 510080, China.
Background: Triglyceride-glucose-BMI (TyG-BMI) index is a surrogate marker of insulin resistance and an important predictor of cardiovascular disease. However, the predictive value of TyG-BMI index in the progression of non-severe aortic stenosis (AS) is still unclear.
Methods: The present retrospective observational study was conducted using patient data from Aortic valve diseases RISk facTOr assessmenT andprognosis modeL construction (ARISTOTLE).
J Cardiothorac Surg
January 2025
Department of Paediatrics, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth, Maharashtra, Pune, 411018, India.
Background: Proton pump inhibitors (PPIs) are commonly used for managing gastroesophageal disorders but concerns about their potential association with increased stroke risk have emerged, especially among patients with pre-existing cardiovascular conditions such as acute coronary syndrome (ACS). This systematic review and meta-analysis aim to assess the risk of stroke associated with PPI use, stratified by the presence or absence of pre-existing CVD.
Methods: This review was conducted following the PRISMA guidelines and included studies up to March 2024 from PubMed, Embase, and Web of Science.
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