AI Article Synopsis
- The report presents a new building block designed for Fmoc/Bu solid phase peptide synthesis specifically for β-linked -GlcNAcylated peptides.
- This building block features acid labile silyl ether protecting groups that can be completely removed during TFA-mediated peptide cleavage.
- The use of this new building block simplifies the synthesis process, reducing the number of steps and eliminating the need for intermediate purification compared to other methods.
Article Abstract
In this report, we introduce a novel building block for Fmoc/Bu solid phase peptide synthesis (SPPS) of β-linked -GlcNAcylated peptides. This building block carries acid labile silyl ether protecting groups, which are fully removed under TFA-mediated peptide cleavage conditions from the resin, thus requiring fewer synthetic steps and no intermediate purification as compared to other acid or base labile protecting group strategies.
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| http://dx.doi.org/10.1039/d1ob00510c | DOI Listing |
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