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Upregulated Expression of CYBRD1 Predicts Poor Prognosis of Patients with Ovarian Cancer. | LitMetric

AI Article Synopsis

  • * The study utilized data from The Cancer Genome Atlas (TCGA) to analyze the relationship between CYBRD1 expression and various clinicopathological traits, revealing that higher CYBRD1 levels are linked to worse overall survival (OS) and serve as an independent predictor of poor prognosis.
  • * Additionally, increased CYBRD1 expression correlates with certain immune cell types and pathways, suggesting its role in altering the immune microenvironment and pointing to potential mechanisms like ferroptosis and

Article Abstract

Cytochrome b reductase 1 (CYBRD1) promotes the development of ovarian serous cystadenocarcinoma (OV). We assessed the function of CYBRD1 in OV underlying The Cancer Genome Atlas (TCGA) database. The correlation between clinicopathological characteristics and CYBRD1 expression was estimated. The Cox proportional hazards regression model and the Kaplan-Meier method were applied to identify clinical features related to overall survival and disease-specific survival. Gene set enrichment analysis (GSEA) was applied to identify the relationship between CYBRD1 expression and immune infiltration. CYBRD1 expression in OV was significantly associated with poor outcomes of primary therapy and FIGO stage. Patients with high levels of CYBRD1 expression were prone to the development of a poorly differentiated tumor and experience of an unfavorable outcome. CYBRD1 expression had significant association with shorter OS and acts as an independent predictor of poor outcome. Moreover, enhanced CYBRD1 expression was positively associated with Tem, NK cells, and mast cells but negatively associated with CD56 bright NK cells and Th2 cells. CYBRD1 expression may serve as a diagnostic and prognostic indicator of OV patients. The mechanisms of poor prognosis of CYBRD1-mediated OV may include increased iron uptake, regulation of immune microenvironment, ferroptosis related pathway, and ERK signaling pathway, among which ferroptosis and ERK signaling pathway may be important pathways of CYBRD1-mediated OV. Furthermore, we verified that CYBRD1 was upregulated in OV and significant correlated with lymph nodes metastasis, advanced stage, poor-differentiated tumor, and poor clinical prognosis in East Hospital cohort. The results of this study may provide guidance for the development of optimal treatment strategies for OV.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8478559PMC
http://dx.doi.org/10.1155/2021/7548406DOI Listing

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