Objectives: Sepsis is a life-threatening medical emergency. There is a paucity of information on whether quality improvement approaches reduce the in-hospital sepsis caseload or save lives and decrease the healthcare system and society's cost at the provincial/national levels. This study aimed to assess the outcomes and economic impact of a province-wide quality improvement initiative in Canada.
Design: Retrospective population-based study with interrupted time series and return on investment analyses.
Setting: The sepsis cases and deaths averted over time for British Columbia were calculated and compared with the rest of Canada (excluding Quebec and three territories).
Patients: Aggregate data were obtained from the Canadian Institute for Health Information on risk-adjusted in-hospital sepsis rates and sepsis mortality in acute care sites across Canada.
Interventions: In 2012, the British Columbia Sepsis Network was formed to reduce sepsis occurrence and mortality through education, knowledge translation, and quality improvement.
Measurements And Main Results: A return on investment analysis compared the financial investment for the British Columbia Sepsis Network with the savings from averted sepsis occurrence and mortality. An estimated 981 sepsis cases and 172 deaths were averted in the post-British Columbia Sepsis Network period (2014-2018). The total cost, including the development and implementation of British Columbia Sepsis Network, was $449,962. Net savings due to cases averted after program costs were considered were $50.6 million in 2018. This translates into a return of $112.5 for every dollar invested.
Conclusions: British Columbia Sepsis Network appears to have averted a greater number of sepsis cases and deaths in British Columbia than the national average and yielded a positive return on investment. Our findings strengthen the policy argument for targeted quality improvement initiatives for sepsis care and provide a model of care for other provinces in Canada and elsewhere globally.
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http://dx.doi.org/10.1097/CCM.0000000000005353 | DOI Listing |
Intimate partner violence (IPV) persists as a cause of short-term, long-term, and chronic health consequences. The elevated risk of IPV during pregnancy and the postpartum period (P-IPV) is commonly attributed to increased demands for child bearers and intimate partners. P-IPV may impact the health of the child bearer, developing fetus, and post-birth child.
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December 2024
Division of Oral and Maxillofacial Radiology, Faculty of Dentistry, University of British Columbia, Vancouver, Canada.
Purpose: This study aimed to evaluate the quality of clinically indicated digital dental panoramic radiographs (DPRs) of children with mixed dentition. Despite the likely widespread use of this modality, recent research detailing errors on DPRs is scarce.
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Front Aging Neurosci
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Department of Ophthalmology and Visual Sciences, Faculty of Medicine, Eye Care Centre, The University of British Columbia, Vancouver, BC, Canada.
Introduction: Apolipoprotein E (ApoE) plays a crucial role in lipid homeostasis, predominantly expressed in astrocytes and to a lesser extent in microglia within the central nervous system (CNS). While the allele is the strongest genetic risk factor for late-onset Alzheimer's disease (AD), its precise role in AD pathogenesis remains elusive. -knockout (-ko) mice, mice expressing human , and human carriers exhibit similar deficits in lipid metabolism, cognitive and behavioral functions, and neurodegeneration.
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Government of Alberta, Forestry and Parks Canmore Alberta Canada.
Wolverines () are a circumboreal species that has experienced substantial range reduction worldwide. In Canada, the wolverine has been extirpated entirely from the east, and from prairie regions in the west. The province of Alberta holds the south-central portion of wolverines' Canadian range, and there they have been designated as since 2001 due to a historical lack of information.
View Article and Find Full Text PDFFront Microbiol
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Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
Evidence suggests that the gut microbiome may play a role in multiple sclerosis (MS). However, the majority of the studies have focused on gut bacterial communities; none have examined the fungal microbiota (mycobiota) in persons with pediatric-onset multiple sclerosis (POMS). We examined the gut mycobiota in persons with and without POMS through a cross-sectional examination of the gut mycobiota from 46 participants' stool samples (three groups: 18 POMS, 13 acquired monophasic demyelinating syndromes [monoADS], and 15 unaffected controls).
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!