AI Article Synopsis
- - This study investigated how body composition, specifically skeletal muscle volume and visceral fat, can predict outcomes in patients with metastatic renal cell carcinoma (RCC) after surgery and systemic therapy.
- - Conducted at a tertiary medical center from 2010 to 2017, the research analyzed patient data and found that more skeletal muscle and less visceral fat were linked to better survival rates.
- - Results indicated that higher skeletal muscle volume was associated with less aggressive cancer grades, suggesting that body composition factors can significantly influence both the clinical outcomes and survival of RCC patients.
Article Abstract
Background/aim: This study analyzed the ability of body composition to predict the outcome of patients with metastatic renal cell carcinoma (RCC) who received cytoreductive nephrectomy followed by systemic therapy.
Patients And Methods: A retrospective study was conducted from December 2010 to November 2017 in a single tertiary medical center. The medical charts and computed tomography images were reviewed. Statistical analysis included oncological features, their correlation with body composition factors, and overall survival.
Results: Skeletal muscle volume was significantly higher in patients with Fuhrman grade 2 RCC than those with grade≥3. Patients with intermediate International Metastatic RCC Database Consortium risk had significantly higher BMI and skeletal muscle compared to those with poor risk. Multivariate analysis showed that increased skeletal muscle and decreased visceral adipose tissue were significant predictors of a better overall survival.
Conclusion: Body composition highly correlated with the oncological features of metastatic RCC and impacted survival.
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| http://dx.doi.org/10.21873/anticanres.15339 | DOI Listing |
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