Bioactivity-guided isolation of compounds from with antibacterial activity against .

Bioactivity-guided fraction of an extract of to identify antibacterial compounds against , led to the isolation of two new compounds, (2″)-5-methoxy-7-hydroxy-8-lavandulylchromone (13) and (2,)-(-)-sophobiflavonoid CE (19), and 18 known flavonoids, (6a,11a)-(-)-maackiain (1), (2)-(-)-8-prenylnaringenin (2), (2)-(-)-exiguaflavanone K (3), (2)-(-)-sophoraflavanone G (4), (2)-(-)-leachianone A (5), (2)-(-)-kushenol E (6), (2)-(-)-leachianone G (7), (±)-kushenol F (8), (2)-(-)-kurarinone (9), (2)-(-)-kurarinol (10), (2 ,3)- (+)-3,7,4'-trihydroxy-5-methoxy-8-prenylflavanone (11), (2)-(-)-isoxanthohumol (12), (2)-(-)-2'-methoxykurarinone (14), (2 ,3)-(+)-kushenol I (15), calycosin (16), kuraridin (17), (2)-(-)-kushenol A (18), and trifolirhizin (20). Their structures were elucidated based on NMR, MS, and CD spectroscopic analysis. Among them, , , , and exerted modest antibacterial activity against , with MIC of 128-256 μg/mL for and 256-512 μg/mL for , and .