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Molecular and cellular regulation of neurotensin receptor under acute and chronic agonist stimulation.
Peptides
October 2006
INSERM U673-UMPC, Hôpital Saint-Antoine, Bâtiment Raoul Kourilsky, 184 rue du Faubourg Saint-Antoine, 75571 Paris Cedex 12, France.
Neurotensin is a tridecapteptide acting mostly in the brain and gastrointestinal tract. NT binds two G protein coupled receptors (GPCR), NTS1 and NTS2, and a single transmembrane domain receptor, NTS3/gp95/sortilin receptor. NTS1 mediates the majority of NT action in neurons and the periphery.
View Article and Find Full Text PDFProteinase 3 mRNA expression is induced in monocytes but not in neutrophils of patients with cystic fibrosis.
FEBS Lett
September 1999
Inserm U 417, Hôpital Saint-Antoine, Bâtiment Raoul Kourilsky, 184 Rue du Faubourg St. Antoine, 75571, Paris Cedex 12, France.
Proteinase 3 (PR3), a serine proteinase which can degrade lung tissue, is present in the cystic fibrosis (CF) sputum. In the present study, PR3 protein and mRNA expression was determined in circulating neutrophils and monocytes. CF neutrophils contained similar PR3 concentrations as healthy controls and poorly expressed PR3 mRNA.
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