AI Article Synopsis
- This study focused on creating and testing orally disintegrating tablets (ODTs) that combine levetiracetam (LEV) and carbamazepine (CBZ) for epilepsy treatment using two preparation methods: lyophilization and direct compression.
- The direct compression method showed suitable flow properties for powder blending, with quality control tests indicating both formulations had desirable characteristics like fast disintegration and low friability.
- The combination of CBZ and LEV in the ODTs resulted in more effective seizure reduction in a rat model compared to treatment with either drug alone, suggesting that this formulation could enhance epilepsy management.
Article Abstract
This study aimed to prepare and characterize the orally disintegrating tablet (ODT) formulations containing the combination of levetiracetam (LEV) and carbamazepine (CBZ) (CBZ + LEV combination) for the treatment of epilepsy. The ODT formulations were prepared using the lyophilization (L) and direct compression (DC) methods. The flowability of the mixed powders used for DC formulation was evaluated. The quality control tests for the ODTs were performed. Also, the antiepileptic effects of pure drugs, their combination, and the suspension of CBZ + LEV-DC-ODT formulation were evaluated in the rats with pentylenetetrazole (PTZ)-induced epilepsy model. The obtained results for the mixed powders of the DC formulation (angle of repose: 26.18 ± 0.794°; compressibility index: 15.24 ± 0.764%) suggest that the flow properties of the powder blend were suitable for the preparation of CBZ + LEV-ODT using DC method. The mean values of diameter and hardness of L-ODTs and DC-ODTs were found to be 16.87 mm and 16.18 mm and 11.96 N and 30.11 N, respectively. The friability of both formulations was <1%. Both formulations were disintegrated in seconds. Drugs in L-ODT had faster dissolution than those in DC-ODT. Compared to the seizure scores obtained for the groups treated with LEV or CBZ, generally, there was a higher decrease in seizure scores in the groups treated with CBZ + LEV combination or the suspension of CBZ + LEV-DC-ODTs. Consequently, the ODT formulations containing the CBZ + LEV combination might be beneficial in the treatment of epilepsy.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/03639045.2021.1988094 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
In brief: Femlyv - an orally disintegrating hormonal contraceptive.
Med Lett Drugs Ther
December 2024
Development studies on the orodispersible freeze-dried platforms for lurasidone hydrochloride - Understanding the effect of amino acid additive and lyophilization stage.
Int J Pharm
December 2024
Department of Pharmaceutical Technology, Medical University of Białystok, Mickiewicza 2c, 15-222 Bialystok, Poland. Electronic address:
In this study, lyophilizates with the second-class antipsychotic agent lurasidone hydrochloride were developed as orodispersible platforms to improve patients' adherence. The primary aim was to evaluate the effect of the amino acid additive (L-arginine, L-lysine, L-histidine) and the freeze-drying stage on the pharmaceutical performance of the designed formulations. The composition was initially optimized using an experimental design approach.
View Article and Find Full Text PDFEnhancing Buccal Drug Delivery: The Impact of Glycerol in Slot-Die-Coated Pectin Films.
Mol Pharm
December 2024
Department of Health Technology, Technical University of Denmark, Oersteds Plads 344B, 2800 Kgs. Lyngby, Denmark.
Buccal delivery offers a promising alternative to e.g., oral or parenteral drug administrations by leveraging the mucosal membranes of the mouth to enhance drug absorption and enhance patient compliance.
View Article and Find Full Text PDFTaste Masking Study of Cocoa Butter Fast Melt Tablet (FMT) Formulations Containing Memantine Hydrochloride.
Int J Pharm Compd
December 2024
Shenkang Education Technology, Shanghai, China.
Article Synopsis
- - The Fast Melt Tablet (FMT) is a new type of quickly dissolving tablet that uses cocoa butter to melt at body temperature, enhancing its effectiveness when taken orally.
- - The study aimed to improve the taste of FMT containing memantine hydrochloride by using artificial sweeteners like aspartame and acesulfame K; six formulations were tested to find the best flavor masking.
- - Formulation T7, using 30mg of aspartame, was found to effectively mask the bitter taste and has desirable properties for commercialization, showing potential as an easy-to-take treatment for Alzheimer's disease.
Biopolymer-based oral films integrated with probiotic active compounds for improved health applications.
Arch Microbiol
November 2024
Vocational School of Health Services, Department of Medical Services and Techniques, Bilecik Şeyh Edebali University, Bilecik, 11100, Turkey.
Orally dissolving films (ODFs) have emerged as a versatile platform that combines convenience, efficacy, and patient compliance. In this study, the cell-free supernatant of the oral probiotic Streptococcus salivarius M18 was incorporated into various biopolymer-based ODF formulations, evaluated for demolding, fragility, and flexibility. The combination of carboxymethyl cellulose, sodium alginate, and glycerol successfully formed stable films.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!