AI Article Synopsis
- Hypercalcemia, often seen in cancer, is typically linked to parathyroid hormone activation but can also be caused by other factors, as shown in a specific case.
- A 76-year-old man experienced hypercalcemia due to excessive production of 1,25-dihydroxyvitamin D resulting from a high-grade fetal lung adenocarcinoma, with the tumor and surrounding cells showing a key enzyme related to this overproduction.
- After surgically removing the lung tumor, the patient's calcium levels returned to normal, indicating that the cancer-induced 1,25-dihydroxyvitamin D overproduction was the main cause of his hypercalcemia rather than the usual PTH-related mechanisms.
Article Abstract
Hypercalcemia is a common electrolyte abnormality in malignancy and is largely caused by activation of parathyroid hormone (PTH) pathways. We report the case of a 76-year-old man with hypercalcemia primarily owing to 1,25-dihydroxyvitamin D overproduction from a high-grade fetal lung adenocarcinoma. Histologically, the tumor itself and tumor-adjacent macrophages were positive for the CYP27B1 protein, a key enzyme that generates 1,25-dihydroxyvitamin D. Suppression was observed in serum PTH and PTH-related hormone levels, suggesting hypercalcemia is independent of the PTH pathway. Serum calcium level returned to normal after surgical resection of the lung cancer, supporting extrarenal overproduction of 1,25-dihydroxyvitamin D elicited by the tumors is the cause of hypercalcemia in this patient.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474218 | PMC |
| http://dx.doi.org/10.1016/j.jtocrr.2021.100204 | DOI Listing |
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