The Synergistic Effect of Nicotine and on Peri-Implant Infections.

Smoking is considered a key risk factor for implant survival; however, how it interacts with the pathogens in peri-implant infections is not clear. Here, we identified that nicotine, the key component of cigarette smoking, can interact with and synergistically induce peri-implant infections in a rat osteolysis model. The nicotine- combination group increased the gross bone pathology, osteolysis, periosteal reactions, and bone resorption compared to the nicotine or single treated group ( < 0.05). Nicotine did not promote the proliferation of both and , but it can significantly upregulate the expression of staphylococcal protein A (SpA), a key virulence factor of . The nicotine- combination also synergistically activated the expression of RANKL (receptor activator of nuclear factor-kappa B ligand, < 0.05) to promote the development of peri-implant infections. The synergistic effects between nicotine and infection can be a new target to reduce the peri-implant infections.