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The Non-Haemostatic Response of Platelets to Stress: An Actor of the Inflammatory Environment on Regenerative Medicine?
Front Immunol
December 2021
SAINBIOSE, INSERM, U1059, University of Lyon, Saint-Etienne, France.
Platelet Signaling in Primary Haemostasis and Arterial Thrombus Formation: Part 2.
Hamostaseologie
November 2018
Division of Clinical and Experimental Haemostasis, Hemotherapy and Transfusion Medicine, University Blood Center, and Haemophilia Comprehensive Care Center, Institute of Transplantation Diagnostics and Cell Therapeutics, Heinrich Heine University Medical Center, Düsseldorf, Germany.
Platelet signal transduction is the focus of this review. While 'classic' platelet signaling through G protein-coupled receptors in response to fluid-phase agonists has been extensively studied, signaling mechanisms linking platelet adhesion receptors such as GPIb-IX-V, GPVI and α2β1 to the activation of αIIbβ3 are less well established. Moreover, 'non-haemostatic' pathways can also activate platelets in various settings, including platelet-immune or platelet-tumour cell interactions, platelet responses to neutrophil extracellular traps, or stimulation by microbial pathogens.
View Article and Find Full Text PDFA dichotomy in platelet activation: Evidence of different functional platelet responses to inflammatory versus haemostatic stimuli.
Thromb Res
December 2018
Sackler Institute of Pulmonary Pharmacology, Institute of Pharmaceutical Science, Room 5.06 Franklin-Wilkins Building, Waterloo Campus, King's College London, London SE1 9NH, UK.
Introduction: Platelets participate in inflammatory disorders through a variety of different functional responses, including chemotaxis, platelet-leukocyte complex formation and facilitation of leukocyte recruitment that are thought to be distinct from platelet aggregation. This may account for why classical anti-platelet drugs have failed to ameliorate inflammatory disorders where platelets are known to participate, suggesting that distinct pathways may control inflammatory and haemostatic functions of platelets. In the present study, we have therefore investigated the effect of different stimuli on several different functions of platelets preferentially involved either in haemostasis or in inflammation.
View Article and Find Full Text PDFThe non-haemostatic role of platelets in systemic lupus erythematosus.
Nat Rev Rheumatol
March 2018
Department of Infectious Diseases and Immunity, Centre de Recherche du CHU de Québec-Université Laval, Quebec City, Quebec, Canada.
Article Synopsis
- Dysregulation of lymphocyte function, autoantibody accumulation, and ineffective clearance of immune complexes are key features of systemic lupus erythematosus (SLE), resulting in chronic inflammation and organ damage.
- Platelets, known for preventing bleeding, also play significant roles in both adaptive and innate immunity by interacting with immune complexes and releasing immunomodulatory molecules.
- Evidence suggests that activated platelets in SLE patients might increase autoantigen levels through microparticle and mitochondrial antigen release, contributing to the disease's pathogenesis.
New horizons in platelet research: understanding and harnessing platelet functional diversity.
Clin Hemorheol Microcirc
June 2016
Recent years have been ripe with discoveries of non-haemostatic platelet functions. This led to the appreciation of the significant, previously unknown, role played by the platelets in various pathologies and regenerative processes. As a result, exciting opportunities for clinical applications in fields as diverse as regenerative medicine and cancer treatment are emerging.
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