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Chronic traumatic encephalopathy: State-of-the-science update and narrative review.

Clin Neuropsychol

January 2025

Departments of Neurology and Anatomy & Neurobiology, Boston University Chobanian & Avedisian School of Medicine, Boston University CTE and Alzheimer's Disease Research Centers, Boston, MA, USA.

Objective: The long-recognized association of brain injury with increased risk of dementia has undergone significant refinement and more detailed study in recent decades. Chronic traumatic encephalopathy (CTE) is a specific neurodegenerative tauopathy related to prior exposure to repetitive head impacts (RHI). We aim to contextualize CTE within a historical perspective and among emerging data which highlights the scientific and conceptual evolution of CTE-related research in parallel with the broader field of neurodegenerative disease and dementia.

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This research utilizes time series models to forecast electricity generation from renewable energy sources and electricity consumption. The configuration of optimal parameters for these models typically requires optimization algorithms, but conventional algorithms may struggle with fixed search patterns and limited robustness. To address this, we propose an auto-evolution hyper-heuristic algorithm named AE-GAPB.

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The application of machine learning approaches to classify and predict fertility rate in Ethiopia.

Sci Rep

January 2025

Department of Clinical Pharmacy, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Integrating machine learning (ML) models into healthcare systems is a rapidly evolving field with the potential to revolutionize care delivery. This study aimed to classify fertility rates and identify significant predictors using ML models among reproductive women in Ethiopia. This study utilized eight ML models in 5864 reproductive-age women using Ethiopian Demographic Health Survey (EDHS), 2019 data.

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Evolving Paradigms in the Treatment of Oligometastatic Pancreatic Ductal Adenocarcinoma.

J Gastrointest Cancer

January 2025

Department of Gastrointestinal Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Multiple randomized trials have suggested that the addition of comprehensive metastasis-directed therapy to best systemic therapy improves disease control and survival among patients with oligometastatic disease, even for histologies with a high propensity for rapid spread. Here, we review the growing literature supporting the oligometastatic paradigm in pancreatic ductal adenocarcinoma. We summarize key details from nascent institutional series and reflect on the recently reported phase II randomized EXTEND trial.

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Flood models, while representing our best knowledge of a natural phenomenon, are continually evolving. Their predictions, albeit undeniably important for flood risk management, contain considerable uncertainties related to model structure, parameterization, and input data. With multiple sources of flood predictions becoming increasingly available through online flood maps, the uncertainties in these predictions present considerable risks related to property devaluation.

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