Synergistic protective effect of leaf buds and flowers against cisplatin-induced nephrotoxicity in rats and characterization of its bioactive compounds.

An effective antitumor drug like cisplatin has toxic effects leading to kidney injury. The authors investigated the nephroprotective action of leaf buds (CSB) and its flowers (CSF), both individually and in combined therapy against cisplatin-induced renal injury. Renal functional tests, oxidant, anti-oxidant and histopathology of kidney tissues are assessed. The major findings of the experiment is that the CSB and/or CSF ameliorate the successive conditions of (1) Renal dysfunction (Serum creatinine, urea, uric acid and glucose, protein level present in the urine) (2) The degree of lipid peroxidation (3) Antioxidant enzyme suppression and (4) The destructive renal architecture associated with drug-induced renal toxicity. Result suggests that the combined therapy of CSB and CSF was highly effective when compared to monotherapy in the complete regeneration of destructive cells by drug effect and could be an addition of a new source to the pharmaceutical industry as antioxidant nutrition supplement.