Introduction: This post hoc analysis evaluated the effect of prucalopride on abdominal bloating in participants with chronic idiopathic constipation (CIC) who had moderate to very severe bloating at baseline.
Methods: Data from 6 phase 3/4 studies of prucalopride in participants with CIC were pooled. Abdominal bloating was assessed weekly using a 5-point scale (0-4).
Results: The proportion of bloating responders (≥1-point improvement in abdominal bloating score at week 12) was higher in participants treated with prucalopride (62.1%) vs placebo (49.6%).
Discussion: The prucalopride arm had a higher proportion of bloating responders vs placebo in this study population.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8715996 | PMC |
| http://dx.doi.org/10.14309/ajg.0000000000001521 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Fear of cancer recurrence in long-term colorectal cancer survivors: a nationwide cross-sectional study.
J Cancer Surviv
January 2025
The Daffodil Centre, The University of Sydney, A Joint Venture With Cancer Council NSW, 153 Dowling St, Woolloomooloo, Sydney, NSW, 2011, Australia.
Purpose: Knowledge about fear of cancer recurrence (FCR) among recurrence-free long-term colorectal cancer survivors (CRCS) is limited. This national cross-sectional study aimed to (1) assess the prevalence and correlates of FCR among CRCS; (2) investigate associations between colorectal cancer-specific symptoms and FCR; and (3) identify predictors of interest in engaging in FCR treatment.
Methods: We identified 9638 living Danish CRCS, age above 18 years, diagnosed between 2014 and 2018 through the Danish Clinical Registries.
Dysmenorrhea Among Women Living in Saudi Arabia: Prevalence, Determinants, and Impact.
Life (Basel)
January 2025
Family and Community Medicine Department, Faculty of Medicine, Jazan University, Jazan 45142, Saudi Arabia.
Dysmenorrhea, or painful menstruation, is one of the most prevalent conditions among adolescents and young females globally, significantly affecting academic performance, quality of life, and social interactions. Despite its high prevalence, dysmenorrhea has been rarely investigated in Saudi Arabia, resulting in a scarcity of national data. This study aimed to evaluate the prevalence, severity, and determinants of dysmenorrhea among females in Saudi Arabia.
View Article and Find Full Text PDFA Comprehensive Review of the Usefulness of Prebiotics, Probiotics, and Postbiotics in the Diagnosis and Treatment of Small Intestine Bacterial Overgrowth.
Microorganisms
January 2025
Department of Clinical Biochemistry, Pediatric Institute, Faculty of Medicine, Jagiellonian University Medical College, 30-663 Krakow, Poland.
Small intestinal bacterial overgrowth (SIBO) is a disorder characterized by the excessive growth of bacteria in the small intestine. Bacterial overgrowth disrupts the bacterial balance and can lead to abdominal pain, weight loss, and gastrointestinal symptoms, including bloating, diarrhea, and malabsorption. SIBO is widespread in the population.
View Article and Find Full Text PDFEfficacy of fermented foods in irritable bowel syndrome: a systematic review and meta-analysis of randomized controlled trials.
Front Nutr
January 2025
Department of Gastroenterology, Shaoxing People's Hospital, Shaoxing, China.
Objective: Fermented foods (FFs) may theoretically benefit irritable bowel syndrome (IBS) symptoms, but the role of FFs for IBS patients in the real world is inconsistent and has not been systematically assessed. We performed a systematic review and meta-analysis to examine this issue.
Methods: PubMed, MEDLINE, Embase and Cochrane Library databases were searched up to August 2024.
DIGITAL THERAPEUTIC COMBINING HYPNOSIS AND DIAPHRAGMATIC BREATHING INTERVENTION FOR FUNCTIONAL ABDOMINAL BLOATING (FAB): A FEASIBILITY STUDY.
Clin Transl Gastroenterol
January 2025
Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, NC.
Background And Aims: Abdominal bloating is a difficult symptom to treat. Hypnotherapy and diaphragmatic intervention have separately shown benefit on bloating in prior work but have not been united into a single intervention. We aimed to obtain data on the potential therapeutic impact of a novel audio-recorded bloating treatment for bloating integrating hypnosis and diaphragmatic breathing, with proposed synergistic effect.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!