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Role of CD19 Chimeric Antigen Receptor T Cell Therapy in Idiopathic Inflammatory Myopathies.
J Rheumatol
March 2025
R. Aggarwal, MD, MS, UPMC Myositis Center, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Idiopathic inflammatory myopathies (IIMs) comprise a spectrum of autoinflammatory disease characterized primarily by muscle inflammation, with secondary involvement of diverse organs including joints, skin, lungs, heart, and the gastrointestinal system. Managing these conditions poses considerable challenges, often inflicting profound distress on the afflicted individuals. Encouragingly, the deployment of chimeric antigen receptor (CAR) T cell therapy has demonstrated promising efficacy across various autoimmune diseases, extending hope for ameliorating the burden of IIM.
View Article and Find Full Text PDFPractical utilization of sonography for the assessment of muscle diseases in rheumatology.
Best Pract Res Clin Rheumatol
March 2025
School of Medicine, Division of Rheumatology, Johns Hopkins University, Baltimore, MD, USA. Electronic address:
Muscular manifestations are common complaints encountered in daily rheumatology practice. Magnetic resonance imaging and electromyography are employed to evaluate muscular manifestations associated with myositis and other rheumatologic diseases, but both have limitations that hinder their universal applicability. Ultrasound, on the other hand, has been increasingly used given its utility as a point-of-care tool.
View Article and Find Full Text PDFCardiovascular events in patients with myositis: results from a French retrospective cohort.
RMD Open
March 2025
Department of Cardiology, Sorbonne University, Hospital Saint-Antoine, Paris, France.
Introduction: Idiopathic inflammatory myositis (IIM) are systemic diseases, including dermatomyositis (DM), inclusion body myositis (IBM), immune-mediated necrotising myopathy (IMNM), antisynthetase syndrome (ASSD) and overlap myositis (OM). Patients with IIM have an increased risk of premature death, largely due to cardiovascular events (CVE). The aim of this study was to describe specific and non-specific cardiac involvement in patients with IIM, and to assess the occurrence of CVE.
View Article and Find Full Text PDFMyositis of pterygoid muscles and superior ophthalmic vein and cavernous sinus thrombosis in active Crohn's disease undergoing ustekinumab treatment: a case report and literature review.
Front Pharmacol
February 2025
Department of Pediatric Gastroenterology and Hepatology and nutrition, University Hospitals Leuven, KU Leuven, Leuven, Belgium.
Introduction: Myositis is a rare extra-intestinal presentation in patients with inflammatory bowel diseases (IBD), and its occurrence has only been described in a few case reports. However, it is essential to consider other potential causes as patients with IBD are more susceptible to infections due to their immunocompromised status, which may also be exacerbated by immunosuppressive drugs contributing to myositis. Our case highlights the complexity and challenges in diagnosing and managing myositis in patients with IBD as well as a review of the literature.
View Article and Find Full Text PDFTuberculosis infection in patients with dermatomyositis.
Reumatismo
March 2025
Rheumatology Section, Internal Medicine Department, Italian Hospital of Buenos Aires.
Patients with dermatomyositis (DM) are particularly susceptible to the development of opportunistic infections due to immunosuppression induced by the disease itself and its treatment. We describe three patients who met the diagnostic criteria for DM and developed tuberculous myositis. The first case, a 54-year-old woman, had a positive polymerase chain reaction (PCR) for Mycobacterium tuberculosis detected in a post-mortem muscle biopsy.
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