Introduction: Stromal Vascular Fraction cells (SVFs) and Platelet Rich Plasma (PRP) are clinically proven to aid in cell regeneration and wound healing. The healing effects can be measured by the level of Epidermal Growth Factor (EGF). This study aims to investigate the effect of an SVFs and PRP combination on EGF levels in the anal trauma model.
Method: Twenty-eight adult Wistar rats were divided into 3 groups: Group A consisted of healthy rats as a normal control group; Group B and C underwent modified anal surgical trauma and repair. Group B was treated with saline only and Group C was treated with local injection of a combination of SVFs and PRP after anal surgical repair. The EGF level was subsequently assessed on days 1, 7, and 14.
Results: EGF levels were generally increased in Group C compared to Group B. A one-way ANOVA test result showed significantly increased EGF levels on days 7 (p = 0.038) and 14 (p = 0.018). Based on the linear regression test results, we found that local injection of PRP and SVFs after anal repair on an anal surgical trauma model can increase the EGF level in group C by 36.9% more than that of group B.
Conclusion: The combination of PRP and SVFs can increase the EGF level in the wound healing process of anal trauma. EGF is critical in the anal trauma healing process.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450198 | PMC |
| http://dx.doi.org/10.1016/j.amsu.2021.102773 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Fabrication of a Redox-Reversible Near-Infrared Fluorogenic Probe for Ferroptosis Process Monitoring and the Early Diagnosis of Diabetes.
Anal Chem
January 2025
Key Laboratory of Emergency and Trauma of Ministry of Education, Department of Radiotherapy, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou 571199, China.
Ferroptosis is a type of cell death triggered by the iron-dependent accumulation of lipid peroxides in cells. Diabetes, a chronic metabolic disorder characterized by hyperglycemia, can lead to various health complications. The process of ferroptosis and the progression of diabetes are closely linked to redox homeostasis, which is regulated by the levels of reactive oxygen and sulfur species.
View Article and Find Full Text PDFHigh Glucose-Induced Senescent Fibroblasts-Derived Exosomal miR-497 Inhibits Wound Healing by Regulating Endothelial Cellular Autophagy via ATG13.
Anal Cell Pathol (Amst)
January 2025
Department of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, China.
Fibroblasts play a crucial role in diabetic wound healing, and their senescence is the cause of delayed wound repair. It was reported that fibroblasts can secrete exosomes that can mediate a vital role in diabetic complications. Our purpose is to examine the biological function of high glucose (HG)-induced senescent fibroblasts from the perspective of exosomes and reveal the mechanism at cellular and animal levels.
View Article and Find Full Text PDFEffect of eHMI-equipped automated vehicles on pedestrian crossing behavior and safety: A focus on blind spot scenarios.
Accid Anal Prev
January 2025
Jiangsu Key Laboratory of Urban ITS, Southeast University, Nanjing 211189, China; Jiangsu Province Collaborative Innovation Center of Modern Urban Traffic Technologies, Nanjing 211189, China; School of Transportation, Southeast University, Nanjing 211189, China. Electronic address:
Blind spot collisions are a critical and often overlooked threat to pedestrian safety, frequently resulting in severe injuries. This study investigates the impact of automated vehicles equipped with external human-machine interfaces (eHMIs) on pedestrian crossing behavior and safety, focusing on scenarios where AVs create mutual blind spots between pedestrians and adjacent traffic. A virtual reality experiment with 51 participants simulated crossing situations in front of yielding trucks with obstructed pedestrian visibility, featuring three eHMIs: 'Walk,' 'Don't Walk,' and 'Caution! Blind Spots'.
View Article and Find Full Text PDFPubic Arch Angle Postural Mobility Evaluation in Different Patient's Positions for Clinical Research.
Cureus
December 2024
Yoga and Cranial Osteopathy, ApsDEHA, Savona, ITA.
Childbirth is a dynamic process involving mutual adaptation between the maternal pelvis and the presenting fetal part. The ability of the pelvis to maintain optimal mobility during labor plays a crucial role in achieving favorable obstetric outcomes. The pubic arch angle (PAA) increases amplitude during pregnancy, showing pelvic tissue adjustment.
View Article and Find Full Text PDFThe Association Between Levator Ani Integrity and Postpartum Ano-Rectal Dysfunction: A Systematic Review.
Int Urogynecol J
January 2025
Department Development and Regeneration, Cluster Urogenital, Abdominal and Plastic Surgery, KU Leuven, Leuven, Belgium.
Introduction And Hypothesis: Pregnancy and delivery are commonly associated with ano-rectal dysfunction. In addition, vaginal delivery may impact both the structure and functionality of the pelvic floor. Herein, we systematically reviewed the literature for the potential association between levator ani muscle (LAM) avulsion and ano-rectal function after childbirth.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!