AI Article Synopsis
- A study examined autoimmune diseases and autoantibodies in 237 people from 17 families with rheumatoid arthritis (RA), finding that hyperthyroidism was more common among RA patients but not significant when RA cases were excluded.
- Thyroid antibodies were more prevalent regardless of RA status, suggesting a possible shared genetic factor between RA and immune thyroid disease, though not linked to the HLA-DR gene.
- Antinuclear factor (ANF) was related to RA and HLA-DR3, but relatives of RA patients did not show increased ANF positivity, while rates of pernicious anemia and related antibodies were as expected.
Article Abstract
The presence of autoimmune diseases and autoantibodies has been studied in 237 individuals from 17 families with two or more members affected by rheumatoid arthritis (RA). Hyperthyroidism occurred significantly more frequently than in a local control population (p less than 0.05), but if the RA cases were excluded this significance was lost. Thyroid cytoplasmic and microsomal antibodies were significantly more common (p less than 0.001), and this remained true if RA sufferers were excluded (p less than 0.01). The prevalence of both clinical thyroid disease and circulating thyroid autoantibodies was similar in the families where RA was associated with HLA-DR4 and in those where no DR4 association was observed. RA and immune thyroid disease may, therefore, share a common inherited factor, but this is unlikely to be at the HLA-DR locus. Antinuclear factor (ANF) was found in association with RA and with HLA-DR3 within the RA group (p less than 0.02). Relatives of RA sufferers did not show any excess of ANF positivity. The prevalence of pernicious anaemia (PA) and gastric parietal cell antibody did not differ from the expected.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1001877 | PMC |
| http://dx.doi.org/10.1136/ard.45.4.323 | DOI Listing |
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