Introduction: A pre-existing implant at the harvesting site might dissuade the surgeon from considering the site as available for bone harvesting. This study aimed to investigate the quantity of cancellous bone graft that can be harvested from a proximal tibia with an inserted nail and to report the clinical outcomes of this bone graft harvesting technique.
Hypothesis: Our hypothesis was that a certain amount of cancellous bone graft could be harvested from a proximal tibia with an inserted nail without compromising the surrounding environment and outcome of nonunion treatment.
Material And Methods: Bone grafting from an ipsilateral proximal tibia with an inserted nail was performed in 32 patients for treating defect nonunion. The amount of harvested bone was measured using three parameters (weight, height, and volume). The effects of the proximal locking screw position on the quantity and location of bone graft harvest were analyzed. Clinical outcomes were evaluated by assessing the radiologic healing of the bone graft site and by assessing the donor site complications.
Results: The mean bone defect volume in the nonunion site was 31.1±18.3 (range, 10.6-87.0) cm. The mean quantity of harvested bone from proximal tibias with an inserted nail was 21.2g, height was 3.9cm, and volume was 26.3 cm. A positive correlation was found between the quantity of harvested bone and the level of the lateral oblique interlocking screw hole in the tibial nail. All grafted bone successfully consolidated in all cases at an average of 5.8 months postoperatively. However, joint penetration during bone harvesting occurred in one case.
Discussion: The bony defect, which measured about 14.3 cm could be filled with cancellous bone from a PT with an existing IM nail, without additional bone graft requirements. Even if an intramedullary nail exists inside the proximal tibia, harvesting cancellous bone at this site can be a viable option without serious complications.
Level Of Evidence: IV; Retrospective descriptive study.
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http://dx.doi.org/10.1016/j.otsr.2021.103084 | DOI Listing |
Clin Otolaryngol
January 2025
School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Introduction: The nasoseptal flap (NSF) has become a widely favoured choice for reconstructing skull base defects following the endoscopic endonasal approach (EEA). However, the exposed septal cartilage and bone at the donor site often require an extended duration for secondary healing. This study investigated whether the free middle turbinate (MT) mucosa grafting at the septal donor site could mitigate post-operative nasal morbidity.
View Article and Find Full Text PDFHum Mol Genet
January 2025
Ophthalmology Department, Tongxiang First People's hospital, No. 1918 Jiaochang East Road, Tongxiang, Zhejiang 314500, China.
Activation of bone morphogenetic protein (BMP) 4 signaling promotes the survival of retinal ganglion cell (RGC) after acute injury. In this study, we investigated the role of the BMP4 signaling pathway in regulating the degeneration of retinal ganglion cells (RGCs) in a mouse glaucoma model and its potential application in retinal stem cell. Our results demonstrate that BMP4-GPX4 not only reduces oxidative stress and iron accumulation but also promotes neuroprotective factors that support the survival of transplanted RSCs into the host retina.
View Article and Find Full Text PDFSwiss Med Wkly
January 2025
Department of Internal Medicine, Clinic for Medical Oncology and Hematology, Municipal Hospital Zurich Triemli, Zurich, Switzerland.
Introduction: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a very rare disease, with unique diagnostic challenges and often dismal outcome. There are no widely accepted treatment guidelines available. Lymphoma-like regimens with or without autologous or allogenic transplantation were the cornerstone of most therapeutic concepts.
View Article and Find Full Text PDFObjectives The optimal dosing schedule strategy for granulocyte colony-stimulating factor (G-CSF) in healthy stem cell donors remains controversial. This study aimed to compare the efficacy of once-daily versus twice-daily G-CSF administration in allogeneic stem cell donors. Materials and methods We retrospectively analyzed data from 388 healthy unrelated donors (282 males, 106 females) who underwent stem cell mobilization at our center between September 2018 and June 2022.
View Article and Find Full Text PDFOrthop J Sports Med
January 2025
Department of Orthopaedic Surgery, Mayo Clinic, Phoenix, Arizona, USA.
Background: It has been demonstrated that an athlete's psychological readiness contributes to one's ability to successfully return to sport (RTS) after anterior cruciate ligament (ACL) reconstruction. However, the effect of graft choice on psychological readiness is not yet understood.
Purpose/hypothesis: The purpose of this study was to evaluate the association between graft choice and an athlete's psychological readiness to RTS.
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