AI Article Synopsis
- A new method for selectively transforming -quinamines into functionalized imidazolidin-2-one derivatives using isocyanates has been developed, utilizing chiral phosphoric acid as a catalyst.
- This process yields high-quality products under mild conditions and can be executed on a larger scale with low catalyst amounts.
- The resulting chiral compounds can be easily converted into other valuable structures while maintaining their enantiopurity, showcasing the method's practical applications in synthesis.
Article Abstract
The development of enantioselective desymmetrization of -quinamines with isocyanates catalyzed by chiral phosphoric acid is reported. The strategy provides concise access to functionalized imidazolidin-2-one derivatives in high yields and enantioselectivities under mild reaction conditions. Remarkably, this reaction could be performed on a gram scale using 5 mol % catalyst loading and the chiral imidazolidin-2-one derivatives could be easily transformed into valuable scaffolds without disturbing the enantiopurity, demonstrating the synthetic utility of this protocol.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.orglett.1c02889 | DOI Listing |
Publication Analysis
Top Keywords
imidazolidin-2-one derivatives
12
chiral phosphoric
8
phosphoric acid
8
desymmetrization -quinamines
8
-quinamines isocyanates
8
access functionalized
8
functionalized imidazolidin-2-one
8
acid catalyzed
4
catalyzed asymmetric
4
asymmetric desymmetrization
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!