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Nanoparticle innovations in targeted cancer therapy: advancements in antibody-drug conjugates.
Naunyn Schmiedebergs Arch Pharmacol
January 2025
Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, 11829, Cairo, Egypt.
Antibody-drug conjugates (ADCs) have emerged as a promising strategy in targeted cancer therapy, enabling the precise delivery of cytotoxic agents to tumor sites while minimizing systemic toxicity. However, traditional ADCs face significant limitations, including restricted drug loading capacity, where an optimal drug-to-antibody ratio (DAR) is crucial; low DARs may lead to insufficient potency, while high DARs can cause rapid clearance and increased toxicity. Additionally, ADCs often suffer from instability in circulation due to the potential for premature release of cytotoxic agents, resulting in off-target effects and reduced therapeutic efficacy.
View Article and Find Full Text PDFDefinition and diagnostic criteria of clinical obesity.
Lancet Diabetes Endocrinol
January 2025
Division of Diabetes & Nutritional Sciences, School of Cardiovascular and Metabolic Medicine & Sciences, King's College London, London, UK; Catholic University of the Sacred Heart, Rome, Italy; University Polyclinic Foundation Agostino Gemelli IRCCS, Rome, Italy.
Detection of necrotic enteritis risk through non-invasive monitoring of Clostridium perfringens in feces.
Poult Sci
January 2025
Ancera, Inc, Branford, CT 06405, USA. Electronic address:
Necrotic enteritis (NE), caused by the gram-positive, anaerobic bacterium, Clostridium perfringens, results in an estimated $6 billion in annual economic losses to the global poultry industry. C. perfringens is part of the normal microflora of the poultry gastrointestinal tract, but damage to the intestinal epithelium can lead to increased cell proliferation and production of toxins which gives rise to disease.
View Article and Find Full Text PDFAnalysis of the anthropogenic effect on River in Salvador Escalante, Michoacán, México.
PeerJ
January 2025
Facultad de Ingeniería Química, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Michoacán, Mexico.
The average annual water availability worldwide is approximately 1,386 trillion cubic hectometers (hm), of which 97.5% is saltwater and only 2.5% is freshwater.
View Article and Find Full Text PDFA roadmap to sustainable management of commercial medicinal and aromatic plants, fungi, and lichens in Nepal.
Conserv Biol
January 2025
Department of Food and Resource Economics, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark.
Thousands of plants, fungi, and lichen species are traded every year. Although sustainable use is critical for livelihoods and biodiversity conservation, insufficient data prevent detailed sustainability assessments for most species. How can the sustainability of trade in such data-deficient species be enhanced? We considered a country-level example of 300 medicinal and aromatic plant, fungus, and lichen species traded in tens of thousands of tons worth tens of millions of US dollars in and from Nepal annually.
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