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| http://dx.doi.org/10.1136/bcr-2021-244301 | DOI Listing |
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[Acute porphyria as a rare etiology of PRES].
Rev Fac Cien Med Univ Nac Cordoba
September 2024
Hospital Clinico Universitario Lozano Blesa. Zaragoza. España.
Article Synopsis
- Porphyria is a rare disorder that affects heme metabolism, leading to various symptoms, including abdominal pain, vomiting, and seizures.
- A clinical case of a 29-year-old man highlights the importance of diagnostic imaging (CT and MRI), which revealed parieto-occipital involvement and confirmed porphyria through lab tests.
- Acute porphyria attacks should be considered in young patients presenting with seizures and abdominal pain, especially when typical causes of posterior reversible encephalopathy syndrome (PRES) are absent.
Common functional mechanisms underlying dynamic brain network changes across five general anesthetics: A rat fMRI study.
CNS Neurosci Ther
July 2024
Department of Anesthesiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Background: Reversible loss of consciousness is the primary therapeutic endpoint of general anesthesia; however, the drug-invariant mechanisms underlying anesthetic-induced unconsciousness are still unclear. This study aimed to investigate the static, dynamic, topological and organizational changes in functional brain network induced by five clinically-used general anesthetics in the rat brain.
Method: Male Sprague-Dawley rats (n = 57) were randomly allocated to received propofol, isoflurane, ketamine, dexmedetomidine, or combined isoflurane plus dexmedetomidine anesthesia.
Posterior reversible encephalopathy syndrome: A case report.
Radiol Case Rep
July 2024
UFR 2S, Gaston Berger University, Saint-Louis, Senegal.
Posterior Reversible Encephalopathy Syndrome (PRES) is a radio-clinical entity associating reversible damage of the central nervous system and typical brain imaging. The clinical context is often suggestive with, in half of cases, the use of vasoactive substances (cannabis, antidepressants, nasal decongestants) and/or postpartum. The etiologies are dominated by hypertensive encephalopathy, preeclampsia, eclampsia, immunosuppressive therapies, and systemic diseases.
View Article and Find Full Text PDFCOVID-19-related posterior reversible encephalopathy syndrome: insights from a clinical case.
Encephalitis
January 2024
Department of Diagnostic and Interventional Radiology, Eberhard-Karls University, Tübingen, Germany.
In the present case report, a 50-year-old female presented with hemiparesis and blurred vision and was subsequently diagnosed with posterior reversible encephalopathy syndrome (PRES) associated with coronavirus disease 2019 (COVID-19). Magnetic resonance imaging revealed cortico-subcortical edema with hyperintensities bilaterally in the frontoparietal and bi-occipital regions. Although PRES is a neurotoxic disorder that typically affects white matter of the brain and often is associated with hypertension, renal failure, and autoimmune disorders, recent studies have suggested that COVID-19 increases the risk of PRES.
View Article and Find Full Text PDFPostmortem brain 7T MRI with minimally invasive pathological correlation in deceased COVID-19 subjects.
Insights Imaging
January 2022
Departamento de Patologia, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil.
Background: Brain abnormalities are a concern in COVID-19, so we used minimally invasive autopsy (MIA) to investigate it, consisting of brain 7T MR and CT images and tissue sampling via transethmoidal route with at least three fragments: the first one for reverse transcription polymerase chain reaction (RT-PCR) analysis and the remaining fixed and stained with hematoxylin and eosin. Two mouse monoclonal anti-coronavirus (SARS-CoV-2) antibodies were employed in immunohistochemical (IHC) reactions.
Results: Seven deceased COVID-19 patients underwent MIA with brain MR and CT images, six of them with tissue sampling.
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