This work discusses the present-day limitations of current commercial vaccines for broilers and layers and explores a novel approach towards poultry vaccination using biodegradable nanoparticle vaccines against . With the increasing global population and poultry production and consumption, is a potential health risk for humans. The oral administration of killed or inactivated vaccines would provide a better alternative to the currently commercially available vaccines for poultry. However, there are currently no commercial oral killed-vaccines against for use in broilers or layers. There is a need for novel and effective interventions in the poultry industry. Polymeric nanoparticles could give way to an effective mass-administered mucosal vaccination method for The scope of this work is limited to polymeric nanoparticles against for use in broilers and layers. This review is based on the information available at the time of the investigation.
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http://dx.doi.org/10.3390/vaccines9091041 | DOI Listing |
Sci Rep
December 2024
Departments of Animal and Food Sciences, Biological Sciences, Medical and Molecular Sciences, and Microbiology Graduate Program, University of Delaware, Newark, DE, USA.
The transcriptional regulation of gene expression in the latter stages of follicular development in laying hen ovarian follicles is not well understood. Although differentially expressed genes (DEGs) have been identified in pre-recruitment and pre-ovulatory stages, the master regulators driving these DEGs remain unknown. This study addresses this knowledge gap by utilizing Master Regulator Analysis (MRA) combined with the Algorithm for the Reconstruction of Accurate Cellular Networks (ARACNe) for the first time in laying hen research to identify master regulators that are controlling DEGs in pre-recruitment and pre-ovulatory phases.
View Article and Find Full Text PDFPoult Sci
December 2024
Department of Pathology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh 2202, Bangladesh. Electronic address:
Respiratory viral infections have a considerable detrimental impact on animal health as well as significant financial consequences in the poultry industry. The primary aim of this study is to investigate the major pathogens involved in respiratory diseases of poultry, the co-infection rate, and their epidemiological distribution in commercial chicken farms in Bangladesh. From June 2022 to December 2023, 300 pooled samples (swabs from live birds, and respiratory tissues from dead birds) were collected from the selected poultry farms where respiratory outbreaks were noticed.
View Article and Find Full Text PDFMicrobiol Spectr
December 2024
Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China.
Unlabelled: In poultry, fowl adenovirus (FAdV) and co-infected viruses (such as avian hepatitis E virus, aHEV) are likely to cause decreased egg production, inclusion body hepatitis, and pericardial effusion syndrome. From July to September 2023, eight poultry farms of commercial broilers and commercial layers suffered from increased mortality, decreased egg production, and the presence of hydropericardium-hepatitis syndrome-like gross lesions in Shaanxi province, China. To determine the source of the infection, the viruses of aHEV, FAdV, avian leukosis virus (ALV), Marek's disease virus (MDV), Newcastle disease virus (NDV), and H9N2 avian influenza virus (AIV) were detected.
View Article and Find Full Text PDFPLoS One
December 2024
Secure Food Systems Team, University of Minnesota, Saint Paul, Minnesota, United States of America.
Following confirmation of the first case of the ongoing U.S. HPAI H5N1 epizootic in commercial poultry on February 8, 2022, the virus has continued to devastate the U.
View Article and Find Full Text PDFFront Microbiol
November 2024
Department of Microbiology and Hygiene, Bangladesh Agricultural University, Mymensingh, Bangladesh.
Background: Fowl adenovirus (FAdV) is a globally distributed virus that inflicts significant economic losses on the poultry industry. The study aimed at pathological investigation, molecular characterization, isolation, and pathogenicity determination of FAdV from commercial poultry.
Methods: A total of 86 liver samples were collected from 80 commercial chicken farms.
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