AI Article Synopsis
- Antiretroviral therapy (ART) effectively suppresses HIV-1 replication but doesn't eliminate the virus entirely, leading to challenges in finding a cure.* -
- HIV-1 latent reservoirs remain in people on ART, and these reservoirs are not completely inactive, as viral RNA can still be detected.* -
- This review focuses on how viral RNA processing might contribute to the persistence of these HIV-1 reservoirs and the potential clinical impacts of these findings.*
Article Abstract
Antiretroviral therapy (ART) suppresses HIV-1 replication but does not eradicate the virus. Persistence of HIV-1 latent reservoirs in ART-treated individuals is considered the main obstacle to achieving an HIV-1 cure. However, these HIV-1 reservoirs are not transcriptionally silent, and viral transcripts can be detected in most ART-treated individuals. HIV-1 latency is regulated at the transcriptional and at multiple post-transcriptional levels. Here, we review recent insights into the possible contribution of viral RNA processing to the persistence of HIV-1 reservoirs, and discuss the clinical implications of persistence of viral RNA species in ART-treated individuals.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471011 | PMC |
| http://dx.doi.org/10.3390/v13091751 | DOI Listing |
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