A neutrally buoyant circular particle migration in two-dimensional (2D) Poiseuille channel flow driven by pulsatile velocity is numerical studied by using immersed boundary-lattice Boltzmann method (IB-LBM). The effects of Reynolds number (25≤Re≤200) and blockage ratio (0.15≤k≤0.40) on particle migration driven by pulsatile and non-pulsatile velocity are all numerically investigated for comparison. The results show that, different from non-pulsatile cases, the particle will migrate back to channel centerline with underdamped oscillation during the time period with zero-velocity in pulsatile cases. The maximum lateral travel distance of the particle in one cycle of periodic motion will increase with increasing Re, while k has little impact. The quasi frequency of such oscillation has almost no business with Re and k. Moreover, Re plays an essential role in the damping ratio. Pulsatile flow field is ubiquitous in aorta and other arteries. This article is conducive to understanding nanoparticle migration in those arteries.
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http://dx.doi.org/10.3390/mi12091075 | DOI Listing |
Mol Med Rep
March 2025
The First Central Clinical School, Tianjin Medical University, Tianjin 300000, P.R. China.
Hepatocellular carcinoma (HCC) is a common cause of cancer‑related mortality and morbidity worldwide. While iodine‑125 (I) particle brachytherapy has been extensively used in the clinical treatment of various types of cancer, the precise mechanism underlying its effectiveness in treating HCC remains unclear. In the present study, MHCC‑97H cells were treated with I, after which, cell viability and proliferation were assessed using Cell Counting Kit‑8, 5‑ethynyl‑2'‑deoxyuridine and colony formation assays, cell invasion and migration were evaluated using wound healing and Transwell assays, and cell apoptosis was determined using flow cytometry.
View Article and Find Full Text PDFAnn Sci
January 2025
Niels Bohr Institute, Copenhagen University, Copenhagen, Denmark.
So-called antimatter in the form of elementary particles such as positive electrons (antielectrons alias positrons) and negative protons (antiprotons) has for long been investigated by physicists. However, atoms or molecules of this exotic kind are conspicuously absent from nature. Since antimatter is believed to be symmetric with ordinary matter, the flagrant asymmetry constitutes a problem that still worries physicists and cosmologists.
View Article and Find Full Text PDFJ Control Release
January 2025
Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China. Electronic address:
Most subunit antigens often induce suboptimal vaccination efficacy, possibly due to their low immunogenicity and limited ability to migrate to lymph nodes (LNs). Although the emergence of nanovaccine has significantly addressed these challenges, most formulations still require specific biological or chemical modifications to the carrier or antigen for efficient antigen loading. In this study, we report a Pickering emulsion-based nanovaccine that directly utilized antigens and adjuvants as stabilizers, effectively amplifying immune responses without additional physicochemical alterations.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, China; Hubei Industrial Technology Research Institute of Jingchu Special Foods, Jingzhou 434000, China. Electronic address:
In this work, a nanocomposite film, designated as CS/PA, was fabricated by integrating chitosan (CS), porphyrinic porous coordination network (PCN), and silver nanoparticles (AgNPs). PCN modified AgNPs was denoted as PCN-AgNPs (PA). The synthesis of PA was verified through transmission electron microscope, Zeta potential, hydrated particle size, element mapping.
View Article and Find Full Text PDFPharmaceutics
December 2024
Department of Hospital Surgery, Department of Plastic and Reconstructive Surgery, Cosmetology and Cell Technology, Pirogov Russian National Research Medical University (RNRMU), 117997 Moscow, Russia.
Background/objectives: The aim was to study the possibilities of biomedical application of gadolinium oxide nanoparticles (GdO NPs) synthesized under industrial conditions, and evaluate their physicochemical properties, redox activity, biological activity, and safety using different human cell lines.
Methods: The powder of GdO NPs was obtained by a process of thermal decomposition of gadolinium carbonate precipitated from nitrate solution, and was studied using transmission electron microscopy (TEM), X-ray diffraction (XRD), Raman spectroscopy, mass spectrometry, and scanning electron microscopy (SEM) with energy dispersive X-ray analyzer (EDX). The redox activity of different concentrations of GdO NPs was studied by the optical spectroscopy (OS) method in the photochemical degradation process of methylene blue dye upon irradiation with an optical source.
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