Multirotor unmanned aerial vehicles (MUAVs) are becoming more prominent for diverse real-world applications due to their inherent hovering ability, swift manoeuvring and vertical take-off landing capabilities. Nonetheless, to be entirely applicable for various obstacle prone environments, the conventional MUAVs may not be able to change their configuration depending on the available space and perform designated missions. It necessitates the morphing phenomenon of MUAVS, wherein it can alter their geometric structure autonomously. This article presents the development of a morphed MUAV based on a simple rotary actuation mechanism capable of driving each arm's smoothly and satisfying the necessary reduction in workspace volume to navigate in the obstacle prone regions. The mathematical modelling for the folding mechanism was formulated, and corresponding kinematic analysis was performed to understand the synchronous motion characteristics of the arms during the folding of arms. Experiments were conducted by precisely actuating the servo motors based on the proximity ultrasonic sensor data to avoid the obstacle for achieving effective morphing of MUAV. The flight tests were conducted to estimate the endurance and attain a change in morphology of MUAV from "-Configuration" to "-Configuration" with the four arms actuated synchronously without time delay.
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http://dx.doi.org/10.3390/s21186192 | DOI Listing |
PLoS Biol
December 2024
Department of Frontier Life Sciences, Faculty of Life Sciences, Kyoto Sangyo University, Kyoto, Japan.
Quality control of translation is crucial for maintaining cellular and organismal homeostasis. Obstacles in translation elongation induce ribosome collision, which is monitored by multiple sensor mechanisms in eukaryotes. The E3 ubiquitin ligase Znf598 recognizes collided ribosomes, triggering ribosome-associated quality control (RQC) to rescue stalled ribosomes and no-go decay (NGD) to degrade stall-prone mRNAs.
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February 2025
College of Traffic and Transportation, Chongqing Jiaotong University, Chongqing, China. Electronic address:
Static obstacles (tunnel sidewalls, barricades, etc.) on the side of mountainous highways change the spatial range of the road during driving, restricting the driver's freedom of driving while possibly triggering the driver's shy away effect, which poses a specific potential safety hazard. To understand the characteristics of driving behaviour in mountain highway tunnels with different tunnel lengths and lateral obstacles, nine tunnels in Chongqing were selected for real-vehicle tests, and data on driving trajectories, speeds and other metrics were collected from 40 drivers.
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January 2025
Professorship Measurement and Sensor Technology, Chemnitz University of Technology, Chemnitz, Germany. Electronic address:
J Immunother Cancer
October 2024
Department of Stem Cell and Regenerative Medicine, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, Chongqing, China
Triple-negative breast cancer (TNBC) is characterized by high invasion, prone metastasis, frequent recurrence and poor prognosis. Unfortunately, the curative effects of current clinical therapies, including surgery, radiotherapy, chemotherapy and immunotherapy, are still limited in patients with TNBC. In this study, we showed that the heterogeneous expression at the protein level and subcellular location of mesothelin (MSLN), a potential target for chimeric antigen receptor-T (CAR-T) cell therapy in TNBC, which is caused by acidification of the tumor microenvironment, may be the main obstacle to therapeutic efficacy.
View Article and Find Full Text PDFMed Int (Lond)
October 2024
Institute of Global Health, Faculty of Medicine, University of Geneva, 1202 Geneva, Switzerland.
The present study aimed to explore the adherence to and efficiency of skin protection measures among teenagers and young adults. The present study investigated the reasons for sun exposure and the obstacles impeding sun protection. In the summer of 2023, a self-reported questionnaire was posted on the social media account of two high schools, a university, some industrial companies and among the teenage children of a dermatology clinic.
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