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Cancers are a major challenge to health worldwide. Spinel ferrites have attracted attention due to their broad theranostic applications. This study aimed at investigating the antimicrobial, antibiofilm, and anticancer activities of ebselen (Eb) and cerium-nanoparticles (Ce-NPs) in the form of ZnCeFeO on human breast and colon cancer cell lines. Bioassays of the cytotoxic concentrations of Eb and ZnCeFeO, oxidative stress and inflammatory milieu, autophagy, apoptosis, related signalling effectors, the distribution of cells through the cell-cycle phases, and the percentage of cells with apoptosis were evaluated in cancer cell lines. Additionally, the antimicrobial and antibiofilm potential have been investigated against different pathogenic microbes. The ZOI, and MIC results indicated that ZnCeFeO; X = 0.06 specimen reduced the activity of a wide range of bacteria and unicellular fungi at low concentration including (9.5 mm; 6.250 µg/mL), (13.2 mm; 0.390 µg/mL), and (13.5 mm; 0.195 µg/mL). Reaction mechanism determination indicated that after ZnCeFeO; X = 0.06 treatment, morphological differences in were apparent with complete lysis of bacterial cells, a concomitant decrease in the viable number, and the growth of biofilm was inhibited. The combination of Eb with ZFO or ZnCeFeO with γ-radiation exposure showed marked anti-proliferative efficacy in both cell lines, through modulating the oxidant/antioxidant machinery imbalance, restoring the fine-tuning of redox status, and promoting an anti-inflammatory milieu to prevent cancer progression, which may be a valuable therapeutic approach to cancer therapy and as a promising antimicrobial agent to reduce the pathogenic potential of the invading microbes.
Download full-text PDF |
Source |
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466506 | PMC |
http://dx.doi.org/10.3390/ijms221810171 | DOI Listing |
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