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Bmp Signaling Regulates Hand1 in a Dose-Dependent Manner during Heart Development. | LitMetric
The bone morphogenetic protein (Bmp) signaling pathway and the basic helix-loop-helix (bHLH) transcription factor Hand1 are known key regulators of cardiac development. In this study, we investigated the Bmp signaling regulation of during cardiac outflow tract (OFT) development. In and loss-of-function embryos with varying levels of in the heart, is sensitively decreased in response to the dose of expression. In contrast, in the heart is dramatically increased in gain-of-function embryos. We further identified and characterized the Bmp/Smad regulatory elements in . Combined transfection assays and chromatin immunoprecipitation (ChIP) experiments indicated that is directly activated and bound by Smads. In addition, we found that upon the treatment of Bmp2 and Bmp4, P19 cells induced Hand1 expression and favored cardiac differentiation. Together, our data indicated that the Bmp signaling pathway directly regulates expression in a dose-dependent manner during heart development.
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