AI Article Synopsis
- Liquid biopsy refers to the analysis of circulating tumor cells and biomarkers like ctDNA, offering benefits such as easy blood sample collection and ongoing tracking of tumor growth.
- This technique also helps identify drug resistance mechanisms in various cancer treatments, although its effectiveness for melanoma patient management needs more research.
- The review compiles recent findings on CMCs and discusses the biology and detection methods of different liquid biopsy components, supporting the idea that careful biomarker selection can enhance precision medicine in cancer care.
Article Abstract
Liquid biopsy is a common term referring to circulating tumor cells and other biomarkers, such as circulating tumor DNA (ctDNA) or extracellular vesicles. Liquid biopsy presents a range of clinical advantages, such as the low invasiveness of the blood sample collection and continuous control of the tumor progression. In addition, this approach enables the mechanisms of drug resistance to be determined in various methods of cancer treatment, including immunotherapy. However, in the case of melanoma, the application of liquid biopsy in patient stratification and therapy needs further investigation. This review attempts to collect all of the relevant and recent information about circulating melanoma cells (CMCs) related to the context of malignant melanoma and immunotherapy. Furthermore, the biology of liquid biopsy analytes, including CMCs, ctDNA, mRNA and exosomes, as well as techniques for their detection and isolation, are also described. The available data support the notion that thoughtful selection of biomarkers and technologies for their detection can contribute to the development of precision medicine by increasing the efficacy of cancer diagnostics and treatment.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468624 | PMC |
| http://dx.doi.org/10.3390/ijms22189714 | DOI Listing |
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