AI Article Synopsis
- Interleukin 15 (IL-15) is linked to the severity of multiple sclerosis (MS), with a specific subset of IL-15-producing γδ T cells identified in an animal study.
- The study investigated whether this subset exists in humans, analyzing peripheral blood from 29 MS patients and 22 control individuals.
- Results confirmed the presence of IL-15+ γδ T cells in humans, showing that their levels are significantly higher in MS patients and correlate with disease severity, though further research is required to clarify their role in MS.
Article Abstract
Interleukin 15 (IL-15) is known to be involved in the pathogenesis of multiple sclerosis (MS). An animal study revealed a distinct subset of IL-15-producing γδ T cells that correlate with disease severity. The aim of the current study was to test whether such a subset is also present in humans and its importance for the pathogenesis of MS. The peripheral blood from 29 patients with relapsing-remitting MS (including 6 relapses) and 22 controls was stained with monoclonal antibodies and analyzed with flow cytometry. The existence of IL-15+ γδ T cells was confirmed. Moreover, the percentage of IL-15+ γδ T is significantly increased in MS patients and correlates with disease severity. Nevertheless, additional functional studies are needed to fully understand the importance of those cells in multiple sclerosis pathogenesis.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467081 | PMC |
| http://dx.doi.org/10.3390/jcm10184174 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!