AI Article Synopsis
- Lamellar macular holes (LMHs) can worsen over time, but no clear factors predict their progression, leading to a study comparing progressive and stable LMHs using optical coherence tomography (OCT) angiography.
- The study analyzed OCT B scans from 28 patients (14 with progressive tissue loss and 14 stable), evaluating changes in best corrected visual acuity (BCVA) and microvascular parameters.
- Results showed that patients with tissue loss had worse BCVA and lower retinal vascular density and perfusion, indicating that ongoing degeneration of LMHs correlates with visual decline and changes in retinal blood flow.
Article Abstract
Unlabelled: Lamellar macular holes (LMHs) may show morphological and functional deterioration over time, yet no definite prognostic factor for progression has been identified. Since neurovascular retinal unit impairment may take part in neurodegeneration, we compare progressive LMHs to stable ones in optical coherence tomography (OCT) angiography parameters.
Methods: OCT B scans of eyes with LMH were analyzed to detect the presence of tissue loss (TL) over time, allowing us to identify a TL group and a stable (ST) group (14 patients each). The best corrected visual acuity (BCVA) at each considered imaging time point was collected. Lastly, patients underwent macular OCT angiography.
Results: BCVA at last follow up was significantly reduced in the TL group compared to both the ST group and TL group baseline assessment. SCP foveal vessel density (VD), SCP and deep capillary plexus (DCP) perfusion density (PD) and parafoveal PD were lower in the TL group. Linear correlations between quantitative TL over time and parafoveal PD in SCP and between the speed of TL and BCVA variation during follow up were also detected.
Conclusions: TL in LMHs is associated with both OCT angiography modifications and BCVA deterioration over time. We suggest these findings to be a manifestation of foveal Muller cell impairment in progressive LMHs.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466957 | PMC |
| http://dx.doi.org/10.3390/diagnostics11091717 | DOI Listing |
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Article Synopsis
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