Nutritional values of ingredients have been and still are the subject of many studies to reduce security margins of nutrients when formulating diets to reduce feed cost. In most studies, pigs are fed a limited amount of feed in a limited number of meals that do not represent how pigs are fed in commercial farm conditions. With free access to feed, pigs follow their intrinsic feeding behaviour. Feed intake is regulated by satiety and satiation signals. Reducing the feed intake level or feeding frequency can affect digestibility and transit time and induce metabolic changes. To reduce feed costs, alternative ingredients that are frequently rich in dietary fibre are added to diets. Fibre acts on the digestion process and transit time by decreasing energy density and causing viscosity. Various analyses of fibre can be realised, and the measured fibre fraction can vary. Exogenous enzymes can be added to counteract the effect of fibre, but digestive tract conditions, influenced by meal size and frequency, can affect the efficiency of supplemented enzymes. In conclusion, the frequency and size of the meals can affect the digestibility of nutrients by modulating gastrointestinal tract conditions (pH and transit time), metabolites (glucose and short-chain fatty acids) and hormones (glucagon-like peptide 1 and peptide tyrosine tyrosine).
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http://dx.doi.org/10.3390/ani11092598 | DOI Listing |
Front Pharmacol
December 2024
Systems Pharmacology and Translational Therapeutics Laboratory, The Center for Advanced Studies and Technology (CAST), "G. d'Annunzio" University, Chieti, Italy.
Inflammation plays a critical role in the pathogenesis of various diseases by promoting the acquisition of new functional traits by different cell types. Shared risk factors between cardiovascular disease and cancer, including smoking, obesity, diabetes, high-fat diet, low physical activity, and alcohol consumption, contribute to inflammation linked to platelet activation. Platelets contribute to an inflammatory state by activating various normal cells, such as fibroblasts, immune cells, and vascular cells.
View Article and Find Full Text PDFJ Paleolit Archaeol
January 2025
Human Origins Research Unit, Faculty of Archaeology, Leiden University, Einsteinweg 2, 2333 CC Leiden, The Netherlands.
Unlabelled: The Châtelperronian and Uluzzian techno-complexes are identified in western Europe in the same stratigraphic position, between the late Middle Palaeolithic and other Upper Palaeolithic assemblages. Both industries include retouched artefacts with abrupt retouch and arched backs, and radiometric dating indicates that these two technocomplexes belong to the same window of time. Here, we provide a detailed, qualitative technological comparison of two Châtelperronian and two Uluzzian lithic assemblages based on a collaborative, first-hand examination of these collections.
View Article and Find Full Text PDFTraditional obesity-related public health messaging often includes physical activity (PA) recommendations. However, at the population level, the data are conflicting, especially when comparing different self-reported vs measured techniques across different settings and populations. We measured the association between moderate-to-vigorous intensity PA (MVPA) and prospective weight change across five African-origin populations and the extent to which MVPA attenuated weight change over time.
View Article and Find Full Text PDFReports of radiographic exam evaluation for G-tube malposition in children are limited. Evaluate effectiveness of a new 2-view abdominal radiograph exam protocol instituted to provide 24/7 coverage at 2 affiliated hospitals and replace the prior fluoroscopic G-tube contrast check exam. G-tube radiographic exams performed between December 2019 and May 2022 at 2 affiliated hospitals were identified and retrospective chart review was performed to delineate exam test yield, accuracy, sensitivity, specificity.
View Article and Find Full Text PDFThe degeneration of midbrain dopamine (DA) neurons disrupts the neural control of natural behavior, such as walking, posture, and gait in Parkinson's disease. While some aspects of motor symptoms can be managed by dopamine replacement therapies, others respond poorly. Recent advancements in machine learning-based technologies offer opportunities for unbiased segmentation and quantification of natural behavior in both healthy and diseased states.
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