AI Article Synopsis
- Avian coccidiosis, caused by certain parasites, results in significant economic losses for the poultry industry, highlighting the need for effective vaccines.
- Microneme protein 2 (MIC2) and surface antigen 1 (SAG1) are identified as promising vaccine candidates but their effectiveness is impacted by genetic diversity observed in field isolates.
- A study on Korean isolates revealed low genetic diversity for both genes, but differences in nucleotide diversity and amino acid variations were noted when compared to isolates from other countries, emphasizing the need for broader genetic studies to ensure effective vaccine development.
Article Abstract
Avian coccidiosis is a disease caused by members of the genus . Huge economic losses incurred by the global poultry industry due to coccidiosis have increased the need for cost-effective and easily available recombinant vaccines. Microneme protein 2 (MIC2) and surface antigen 1 (SAG1) of have been recognised as potential vaccine candidates. However, the genetic diversity of the antigens in field isolates, which affects vaccine efficacy, has yet to be largely investigated. Here, we analysed genetic diversity and natural selection of and in Korean isolates. Both genes exhibited low levels of genetic diversity in Korean isolates. However, the two genes showed different patterns of nucleotide diversity and amino acid polymorphism involving the isolates obtained from different countries including China and India. These results underscore the need to investigate the genetic diversity of the vaccine candidate antigens and warrant monitoring of genetic heterogeneity and evolutionary aspects of the genes in larger numbers of field isolates from different geographical areas to design effective coccidial vaccines.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470435 | PMC |
| http://dx.doi.org/10.3390/genes12091418 | DOI Listing |
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