AI Article Synopsis
- There are lots of tiny germs called microbes in our gut and mouth that usually help us, but if they get out of balance, it can lead to problems like colorectal cancer (CRC).
- Researchers are looking into how these microbes can affect cancer treatments by either helping the medicine work better or making it less effective.
- Some studies suggest that changing the balance of these microbes could help improve treatments for CRC, so scientists are trying to understand how to do this in a way that's best for each person.
Article Abstract
In healthy hosts, trillions of microbes colonise the gut and oral cavity in a well-balanced state, maintaining a mutually beneficial relationship. Loss of this balance, termed dysbiosis, is strongly implicated in the pathogenesis of colorectal cancer (CRC). However, the roles of microbiota and dysbiosis in CRC treatment remain poorly understood. Recent studies suggest that the gut microbiota has the ability to affect the host response to chemotherapeutic agents by enhancing drug efficacy, promoting chemoresistance and mediating chemotherapy-induced toxicity and side effects via a variety of mechanisms. Several other studies have also proposed manipulation of the microbiota to optimise CRC treatment. In this review, we summarise the current advancement of knowledge on how microbiota and CRC treatments interact with each other and how this interaction may shed some light on the development of personalised microbiota manipulations that improve CRC treatment outcomes.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468110 | PMC |
| http://dx.doi.org/10.3390/cancers13184623 | DOI Listing |
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