Purpose: To correlate the aqueous humor electrolytes with serum electrolytes in patients with cataract.
Methods: In this study, 348 eyes of patients undergoing cataract surgery, who had presented between 1 January 2019 and 30 June 2020, were included. Serum electrolytes were obtained and 0.15 ml of aqueous humor was obtained during surgery using an insulin syringe via the side port incision. Mean and standard deviation was used to analyze all the categorical and continuous data including all the electrolytes levels. Pearson's correlation of coefficient was used to analyze the comparison between serum and aqueous humor electrolytes. Student T-test was used to compare electrolyte values between the serum and aqueous humor.
Results: We observed a significant correlation of the aqueous humor electrolytes with their serum counterparts. The coefficient of correlation is 0.155, 0.44, and 0.405 for Na+, K+, and Cl-, respectively. There is also a significant increase in the aqueous humor electrolytes as compared to the serum levels.
Conclusion: A significant increase in electrolytes levels in the aqueous humor of cataract patients possibly could have a role in the etiology of cataract.
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http://dx.doi.org/10.4103/ijo.IJO_20_21 | DOI Listing |
Background: Phosphorylated tau (p-tau) 181 was isolated in aqueous humor and was correlated with other measures that might be consistent with Alzheimer's disease (AD) including higher plasma p-tau181 concentrations and lower Montreal Cognitive Assessment (MoCA blind version 7.1) scores.
Method: Blood samples, aqueous humor samples, and MoCA scores were collected from patients at the time of cataract surgery.
Graefes Arch Clin Exp Ophthalmol
January 2025
Hospital Universitario de La Princesa, C/Diego de Leon, 62, 28006, Madrid, Spain.
Purpose: To compare iridian Swept-Source Anterior Segment OCT (SS-AS-OCT) and microbiological features in Aqueous Humor (AH) in patients with Fuchs Uveitis Syndrome (FUS) and Posner-Schlossman Syndrome (PSS).
Methods: Comparative, retrospective-prospective single center study examining 131 eyes from 66 patients, including 33 eyes with PSS, 37 eyes with FUS, and 61 healthy eyes. AH samples were collected from affected eyes in all patients.
Invest Ophthalmol Vis Sci
January 2025
Singapore Eye Research Institute, Singapore.
Purpose: To investigate the aqueous proteomics and metabolomics in low-energy and high-energy femtosecond laser-assisted cataract surgery (FLACS).
Methods: In this prospective observational study, 72 patients were randomized to 3 groups: low-energy FLACS, high-energy FLACS, and conventional phacoemulsification (controls). Aqueous was collected after femtosecond laser treatment or at the beginning of surgery (controls).
Invest Ophthalmol Vis Sci
January 2025
Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, United States.
Purpose: Aqueous humor inflow rate, a key parameter influencing aqueous humor dynamics, is typically measured by fluorophotometry. Analyzing fluorophotometric data depends, inter alia, on the volume of aqueous humor in the anterior chamber but not the posterior chamber. Previous fluorophotometric studies of the aqueous inflow rate in mice have assumed the ratio of anterior:posterior volumes in mice to be similar to those in humans.
View Article and Find Full Text PDFPharmaceutics
November 2024
Guangdong Provincial Key Laboratory of Advanced Drug Delivery, Guangdong Provincial Engineering Center of Topical Precise Drug Delivery System, Guangdong Pharmaceutical University, No. 280 University Town Outer Ring East Road, Guangzhou 510006, China.
Background: Internal ocular diseases, such as macular edema, uveitis, and diabetic macular edema require precise delivery of therapeutic agents to specific regions within the eye. However, the eye's complex anatomical structure and physiological barriers present significant challenges to drug penetration and distribution. Traditional eye drops suffer from low bioavailability primarily due to rapid clearance mechanisms.
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