Virulence
HCEMM-USZ, Department of Microbiology, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary.
Published: December 2021
infections are the most prevalent cause of serious human mycoses and are the third most common pathogens isolated from bloodstream infections in hospitalized patients. is a member of the spp., which have a predilection for causing life-threatening disease in neonates and hospitalized pediatric patients. In this study, we utilized a infection model to analyze the immunological responses to . Our results demonstrate that the Toll pathway in controls proliferation as the Toll signaling mutant flies are highly susceptible to . We also confirmed that the fly is a convenient invertebrate animal model to analyze virulence properties of different species and strains from the complex as proved to be less virulent than and the -mannan deficient Δ/Δ strain showed attenuated pathogenicity in this immunodeficient background. We also found that Persephone protease is not required for detection and activation of Toll pathway during infection. Furthermore, we observed that β-glucan receptor deficient flies where more sensitive to compared to wild-type flies; however, we could not find a clear dependence on the recognition of this receptor and the cell wall β-glucan exposure-induced host response. These studies establish this infection model as an efficient tool in deciphering immune responses to as well as for assessing virulence factors produced by this emerging fungal predator.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8477938 | PMC |
http://dx.doi.org/10.1080/21505594.2021.1980989 | DOI Listing |
Neurobiol Dis
January 2025
Department of Molecular Genetics & Microbiology, University of Florida College of Medicine, Gainesville, FL 32611, USA.
Abnormal tau phosphorylation is a key mechanism in neurodegenerative diseases. Evidence implicates infectious agents, such as Herpes Simplex Virus 1 (HSV-1), as co-factors in the onset or the progression of neurodegenerative diseases, including Alzheimer's disease. This has led to divergence in the field regarding the contribution of viruses in the etiology of neurodegenerative diseases.
View Article and Find Full Text PDFLancet Infect Dis
January 2025
Institut Pasteur, Université Paris Cité, G5 Épidémiologie et Analyse des Maladies Infectieuses, Paris, France. Electronic address:
Background: Plasmodium vivax forms dormant liver stages (hypnozoites) that can reactivate weeks to months after primary infection. Radical cure requires a combination of antimalarial drugs to kill both the blood-stage and liver-stage parasites. Hypnozoiticidal efficacy of the liver-stage drugs primaquine and tafenoquine cannot be estimated directly because hypnozoites are undetectable.
View Article and Find Full Text PDFSci Total Environ
January 2025
Institute of Agrochemistry and Food Technology, IATA-CSIC, Av. Agustín Escardino 7, Paterna, Valencia 46980, Spain. Electronic address:
Human enteric viruses and emerging viruses such as severe acute respiratory syndrome coronavirus 2, influenza virus and monkeypox virus, are frequently detected in wastewater. Human enteric viruses are highly persistent in water, but there is limited information available for non-enteric viruses. The present study evaluated the stability of hepatitis A virus (HAV), murine norovirus (MNV), influenza A virus H3N2 (IAV H3N2), human coronavirus (HCoV) 229E, and vaccinia virus (VACV) in reference water (RW), effluent wastewater (EW) and drinking water (DW) under refrigeration and room temperature conditions.
View Article and Find Full Text PDFComput Methods Programs Biomed
January 2025
Faculty of Engineering Sciences, Kyushu University, Fukuoka, Japan.
Background And Objective: Coughing events are eruptive sources of virus-laden droplets/droplet nuclei. These increase the risk of infection in susceptible individuals during airborne transmission. The oral cavity functions as an exit route for exhaled droplets.
View Article and Find Full Text PDFJ Glob Antimicrob Resist
January 2025
Microbiology Unit, Clinical Pathology Department, Piacenza General Hospital, Piacenza, Italy; Medicine and Surgery Department, University of Parma, Parma, Italy.
Objectives: Infections by Carbapenem-Resistant Enterobacterales in hospitals represent a severe threat but little is known on outbreaks in rehabilitation wards caused by Klebsiella pneumoniae producing Klebsiella pneumoniae Carbapenemase (KPC-Kp). We report an outbreak by KPC-Kp, in a Neurorehabilitation Unit in Italy, analysed through Whole-Genome Sequencing (WGS) for transmission routes reconstruction to improve management of KPC-Kp infections in rehabilitation units.
Methods: We investigated cases and KPC-Kp isolates collected from February to October 2022 from hospital surveillance.
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