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The MET Oncogene Network of Interacting Cell Surface Proteins.
Int J Mol Sci
December 2024
Department of Oncology, University of Turin, Regione Gonzole 10, 10143 Orbassano, Italy.
The MET oncogene, encoding the hepatocyte growth factor (HGF) receptor, plays a key role in tumorigenesis, invasion, and resistance to therapy, yet its full biological functions and activation mechanisms remain incompletely understood. A feature of MET is its extensive interaction network, encompassing the following: (i) receptor tyrosine kinases (RTKs); (ii) co-receptors (e.g.
View Article and Find Full Text PDFRole of the HGF/c-MET pathway in resistance to immune checkpoint inhibitors in advanced non-small cell lung cancer.
Cancer Immunol Immunother
January 2025
Université Paris-Saclay, UVSQ, EA 4340 BECCOH, Boulogne-Billancourt, France.
Most of advanced non-small cell lung cancer (NSCLC) patients will experience tumor progression with immunotherapy (IO). Preliminary data suggested an association between high plasma HGF levels and poor response to IO in advanced NSCLC. Our study aimed to evaluate further the role of the HGF/MET pathway in resistance to IO in advanced NSCLC.
View Article and Find Full Text PDFNewer mitochondrial dynamics and their role of calcium signalling in liver regeneration.
Mitochondrion
November 2024
Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Punjab, India.
Liver regeneration is a crucial process involved in cellular proliferation, differentiation, and tissue repair. Calcium signaling impact key pathways like hepatocyte growth factor-Met-tyrosine kinase (HGF-Met) transduction pathway, the epidermal growth factor receptor (EGFR) signaling and Ca-mediated nuclear SKHep1 cell proliferation pathway. Intracellular hepatocyte calcium stores are considered as base for the induction of ca-mediated regeneration process.
View Article and Find Full Text PDFArticle Synopsis
- Cancer-associated fibroblasts (CAFs) promote tumor growth and alter cancer cells' response to drugs, especially in non-small cell lung cancer (NSCLC) treated with ALK tyrosine kinase inhibitors (TKIs).
- Research identified HGF-MET signaling and the fibronectin-integrin pathway as key mechanisms in CAF-mediated drug resistance, with integrin β1 activation in cancer cells found through flow cytometry.
- Combining MET and integrin inhibitors with ALK TKIs showed greater anti-tumor effects in mouse models, highlighting the need for targeting multiple signaling pathways to improve cancer treatment outcomes.
Integration of QTL and comprehensive analysis in the circulating inflammatory cytokines for pan-cancer.
BMC Cancer
August 2024
Cancer Centre, Capital Medical University affiliated Beijing Friendship Hospital, Beijing, 100050, China.
Background: Chemokines and cytokines are components of the tumor microenvironment and also influence tumorigenesis and its composition. However, whether they genetically proxy tumorigenesis is unclear. For causal inferences, eQTL and pQTL were used to determine the role of chemokines and cytokines in pan-cancer.
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