Fungal biofilms interfere with the wound healing processes. Henceforth, the study aims to fabricate a biomaterial-based nano-scaffold with the dual functionalities of wound healing and antibiofilm activity. Nanofibers comprising acacia gum, polyvinyl alcohol and inclusion complex of eugenol in β-cyclodextrin (EG-NF) were synthesized using electrospinning. Antibiofilm studies were performed on species, and the wound-healing activity was evaluated through an excision wound rat model. The EG-NF potentially eradicated the mature biofilm of species and their clinical isolates. Further, EG-NF also enhanced the re-epithelization and speed of wound healing in rat experiments. The study established the bifunctional applications of eugenol nanofibers as a transdermal substitute with antifungal potency.
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