Background: Livin/BIRC7 is a member of the inhibitors of apoptosis proteins family which are implicated in development of cancer through the inhibition of apoptosis process. This case-control study was intended to investigate livin/BIRC7 gene expression in endometrial hyperplasia and carcinoma and its correlation to some oxidative stress markers in addition to its possible diagnostic performance.
Methods: This study included 90 participants [30 endometrial hyperplasia patients, 30 endometrial carcinoma patients, and 30 healthy controls]. Livin/BIRC7 gene expression was analyzed using quantitative reverse transcriptase-polymerase chain reaction (RT-PCR). Serum catalase activity was assessed by enzyme-linked immunosorbent assay (ELISA) and malondialdehyde level was measured by the colorimetric method.
Results: Livin/BIRC7 gene expression was significantly (p < 0.001) higher in endometrial carcinoma from patients with endometrial hyperplasia when compared to controls. A positive correlation was found between livin/BIRC7 expression and serum catalase activity and malondialdehyde level in endometrial hyperplasia and carcinoma. The detection of livin/BIRC7 in endometrial carcinoma has excellent sensitivity and specificity.
Conclusions: Livin/BIRC7 was overexpressed in endometrial carcinoma with excellent power to differentiate endometrial carcinoma from endometrial hyperplasia or healthy subjects, suggesting that it might be a useful molecular marker for endometrial carcinoma diagnosis.
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http://dx.doi.org/10.1186/s43141-021-00244-w | DOI Listing |
Vet Radiol Ultrasound
January 2025
Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada.
A young, intact, female, American Bulldog was presented for hemorrhagic vaginal discharge. Anemia, thrombocytopenia, leukocytosis with neutrophilia, azotemia, and electrolyte disturbances were detected in the bloodwork. A urachal diverticulum with concurrent uterine distention was identified by ultrasonography and CT.
View Article and Find Full Text PDFDiagnostics (Basel)
December 2024
Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China.
Background: Endometrial proliferative lesions (EPLs) encompass endometrial hyperplasia (EH) and endometrial carcinoma (EC). Atypical endometrial hyperplasia (AEH) is associated with an elevated risk of progression to EC. Patients with polycystic ovarian syndrome (PCOS) exhibit higher serum levels of anti-Müllerian hormone (AMH) and a correspondingly increased incidence of EPLs.
View Article and Find Full Text PDFEur J Surg Oncol
December 2024
Department of Anatomy, Medicine and Surgery, University of Malta, Msida, MSD2080, Malta.
Introduction: Current trends of delaying childbearing and the increasing incidence of endometrial cancer in nulliparous woman necessitate research and development of fertility sparing treatments. Hormonal therapy with progestins offers an alternative to surgical treatment for a select group of patients of reproductive-age, who wish to preserve their reproductive potential.
Materials And Methods: The study evaluates the effectiveness of medroxyprogesterone acetate therapy in patients with early-stage endometrial cancer, atypical endometrial hyperplasia or atypical polypoid adenomyoma, seeking to preserve fertility.
Sci Rep
January 2025
Department of Gynecology, Chongqing Ninth People's Hospital, 69, Jialing Village, Beibei District, Chongqing, 400700, China.
This study investigated the risk factors for endometrial hyperplasia (EH) and endometrial carcinoma (EC) in premenopausal women. The goal was to establish a nomogram model to predict the risk of EH/EC and quantitative standards in clinical practice, which improved the clinical prognosis of EH/EC patients. Data were collected from premenopausal women with suspected EH/EC who underwent hysteroscopic endometrial biopsy.
View Article and Find Full Text PDFTheriogenology
March 2025
Center of Reproductive Physiology and Diagnostic Imaging, Faculty of Veterinary Sciences of the National University of La Plata, Argentina; CONICET, Argentina.
In dogs, the characterization of intraluminal uterine contents has been subjectively carried out by the operators. The aims of this study were: 1) To ultrasonographically describe and compare the echogenicity and heterogeneity of the intraluminal uterine contents in bitches using digital analysis; 2) To assess the cytology of the uterine contents; 3) To evaluate the effect of clinical, ultrasonographic, bacteriological and cytological parameters on intraluminal contents echogenicity and heterogeneity. Twenty-one intact, 3-24 kg, 1-12 years of age, female dogs with ultrasonographically detected uterine content were included.
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