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Inhibition of Neural Crest Cell Migration by Strobilurin Fungicides and Other Mitochondrial Toxicants.
Cells
December 2024
In Vitro Toxicology and Biomedicine, Dept Inaugurated by the Doerenkamp-Zbinden Foundation, University of Konstanz, 78464 Konstanz, Germany.
Cell-based test methods with a phenotypic readout are frequently used for toxicity screening. However, guidance on how to validate the hits and how to integrate this information with other data for purposes of risk assessment is missing. We present here such a procedure and exemplify it with a case study on neural crest cell (NCC)-based developmental toxicity of picoxystrobin.
View Article and Find Full Text PDFExploration of Novel Biomarkers for Neurodegenerative Diseases Using Proteomic Analysis and Ligand-Binding Assays.
Biomedicines
December 2024
Quantitative, Translational and ADME Sciences, AbbVie Deutschland GmbH & Co. KG, Knollstrasse, 67061 Ludwigshafen, Germany.
Background/objectives: Neurodegenerative diseases are a major cause of morbidity and mortality worldwide, and their public health burden continues to increase. There is an urgent need to develop reliable and sensitive biomarkers to aid the timely diagnosis, disease progression monitoring, and therapeutic development for neurodegenerative disorders. Proteomic screening strategies, including antibody microarrays, are a powerful tool for biomarker discovery, but their findings should be confirmed using quantitative assays.
View Article and Find Full Text PDFValidity and Reliability of the Basic Psychological Need Satisfaction and Frustration Scale Among Cancer Survivors in Korean Healthcare Contexts.
Healthcare (Basel)
December 2024
Korea Research Institute for Vocational Education & Training, Social Policy Building, Sejong National Research Complex, 370 Sicheong-daero, Sejong-si 30147, Republic of Korea.
Background/objectives: Basic psychological needs are essential for fostering motivation, self-regulated behaviors, and overall well-being. For cancer survivors, fulfilling these needs is crucial for coping with the various challenges of survivorship and for enhancing psychosocial health. This study aimed to assess the validity and reliability of the Korean version of the Basic Psychological Needs Satisfaction and Frustration Scale (K-BPNSFS) in a cancer survivor population.
View Article and Find Full Text PDFOrganizational citizenship behavior: adaptation and validation of the OCB scale CCOE-R.
Front Psychol
December 2024
GOVCOPP, University of Aveiro, Aveiro, Portugal.
Introduction: Organizational Citizenship Behavior has evolved as a pivotal concept in organizational behavior because of its importance on fostering the success of organizations. Despite its recognized benefits, OCB's dimensions are not consensual in literature. The goal of this paper was to adapt and validated to be used in a broader work context an OCB scale (CCOE-R) initially developed for the Portuguese specific professional context, schools and the education sector.
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