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| http://dx.doi.org/10.1016/j.ijso.2021.100356 | DOI Listing |
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High cellular plasticity state of medulloblastoma local recurrence and distant dissemination.
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January 2025
Beijing Neurosurgical Institute, Beijing 100070, China; China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China. Electronic address:
Medulloblastoma (MB), a heterogeneous pediatric brain tumor, poses challenges in the treatment of tumor recurrence and dissemination. To characterize cellular diversity and genetic features, we comprehensively analyzed single-cell/nucleus RNA sequencing (sc/snRNA-seq), single-nucleus assay for transposase-accessible chromatin sequencing (snATAC-seq), and spatial transcriptomics profiles and identified distinct cellular populations in SHH (sonic hedgehog) and Group_3 subgroups, with varying proportions in local recurrence or dissemination. Local recurrence showed higher cycling tumor cell enrichment, whereas disseminated lesions had a relatively notable presence of differentiated subsets.
View Article and Find Full Text PDFHemodynamic Evaluation of Residual Cavity Growth in a Basilar-Tip Cerebral Aneurysm Post-coiling Using Silent Magnetic Resonance Angiography (MRA): A Case Report.
Cureus
December 2024
Department of Neurological Surgery, Ryofukai Satoh Neurosurgical Hospital, Fukuyama, Hiroshima, JPN.
Coil embolization of cerebral aneurysms often encounters challenges in achieving complete filling of the aneurysm sac due to complex shapes and hemodynamic factors, frequently resulting in the formation of a residual cavity (RC) at the aneurysm neck. The hemodynamic mechanisms underlying RC formation and growth, however, remain poorly understood. Computational fluid dynamics (CFD) analysis, combined with silent MRA free from contrast agents and metal artifacts, offers a promising approach to elucidate these mechanisms, potentially enhancing the clinical management of cerebral aneurysms post-coiling.
View Article and Find Full Text PDFMicrosurgical preservation of lenticulostriate artery perforators in insular glioma: the two point antegrade skeletonization technique.
Acta Neurochir (Wien)
January 2025
Department of Neurosurgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, 226014, Uttar Pradesh, India.
Background: Reaching parenchymal segments of the lateral lenticulostriate artery (LSA) perforators, which represent the medial resection limit in insular gliomas (IG), remains a challenge. The currently described methods are indirect and sometimes, imprecise.
Methods: We report an antegrade direct skeletonization technique to identify these tiny arteries at the medial end of IGs with an illustrative case of grade 2 astrocytoma.
Transketolase attenuates the chemotherapy sensitivity of glioma cells by modulating R-loop formation.
Cell Rep
January 2025
Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China; National Center for Neurological Disorders, Shanghai 200040, China; Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai 200040, China; Neurosurgical Institute of Fudan University, Shanghai 200040, China; Shanghai Clinical Medical Center of Neurosurgery, Shanghai 200040, China. Electronic address:
Glioblastoma (GBM) is a highly lethal malignant brain tumor with poor survival rates, and chemoresistance poses a significant challenge to the treatment of patients with GBM. Here, we show that transketolase (TKT), a metabolic enzyme in the pentose phosphate pathway (PPP), attenuates the chemotherapy sensitivity of glioma cells in a manner independent of catalytic activity. Mechanistically, chemotherapeutic drugs can facilitate the translocation of TKT protein from the cytosol into the nucleus, where TKT physically interacts with XRN2 to regulate the resolution and removal of R-loops.
View Article and Find Full Text PDFNeurosurgical Intervention in Primary Intraventricular Hemorrhage : Experience from a Center in China.
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January 2025
Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.
Objective: Primary intraventricular hemorrhage (PIVH) is a rare type of neurologic disorder and remains a challenge for cerebrovascular surgeons. This study intended to investigate the factors associated with neurosurgical intervention and its impact on outcome after PIVH.
Methods: We retrospectively included consecutive patients with PIVH admitted to at a single tertiary academic medical center in China.
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