Association of Advanced Glycation End Products With Lower-Extremity Atherosclerotic Disease in Type 2 Diabetes Mellitus.

Front Cardiovasc Med

Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.

Published: September 2021

Advanced glycation end products (AGEs) were reported to be correlated with the development of diabetes, as well as diabetic vascular complications. Therefore, this study aimed at investigating the association between AGEs and lower-extremity atherosclerotic disease (LEAD). A total of 1,013 type 2 diabetes patients were enrolled. LEAD was measured through color Doppler ultrasonography. The non-invasive skin autofluorescence method was performed for AGEs measurement. Considering that age plays an important role in both AGEs and LEAD, age-combined AGEs, i.e., AGE index (define as AGEs × age/100) was used for related analysis. The overall prevalence of LEAD was 48.9% (495/1,013). Patients with LEAD showed a significantly higher AGE ( < 0.001), and the prevalence of LEAD increased with ascending AGE levels ( for trend < 0.001). Logistic regression analysis revealed that AGE was significantly positively associated with risk of LEAD, and the odds ratios of presence of LEAD across quartiles of AGE were 1.00, 1.72 [95% confidence interval (CI) = 1.14-2.61], 2.72 (95% CI = 1.76-4.22), 4.29 (95% CI = 2.69-6.85) for multivariable-adjusted model (both for trend < 0.001), respectively. The results were similar among patients of different sexes, body mass index, and with or without diabetes family history. Further, AGE presented a better predictive value for LEAD than glycated hemoglobin A (HbA), with its sensitivity, specificity, and area under the curve of 75.5% (95% CI = 71.6-79.2%), 59.3% (95% CI = 54.9-63.6%), and 0.731 (0.703-0.758), respectively. AGE, the non-invasive measured skin AGEs combined with age, seems to be a more promising approach than HbA in identifying patient at high risk of LEAD.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460767PMC
http://dx.doi.org/10.3389/fcvm.2021.696156DOI Listing

Publication Analysis

Top Keywords

lead
10
age
9
advanced glycation
8
glycation products
8
lower-extremity atherosclerotic
8
atherosclerotic disease
8
type diabetes
8
prevalence lead
8
trend 0001
8
risk lead
8

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!