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Experimental medicine study with stabilised native-like HIV-1 Env immunogens drives long-term antibody responses, but lacks neutralising breadth.
EBioMedicine
January 2025
Imperial College London, Department of Infectious Disease, UK. Electronic address:
Background: We report findings from an experimental medicine study of rationally designed prefusion stabilised native-like HIV envelope glycoprotein (Env) immunogens, representative of global circulating strains, delivered by sequential intramuscular injection.
Methods: Healthy adult volunteers were enrolled into one of five groups (A to E) each receiving a different schedule of one of two consensus Env immunogens (ConM SOSIP, ConS UFO, either unmodified or stabilised by chemical cross-linking, followed by a boost with two mosaic Env immunogens (Mos3.1 and Mos3.
Clinical Manifestations.
Alzheimers Dement
December 2024
Cognitive Neuroscience Center, University of San Andrés, Victoria, Buenos Aires, Argentina.
Background: Automated speech and language analysis (ASLA) represents a powerful innovation for detecting and monitoring persons with or at risk for dementia. Given its cost-efficiency and automaticity, its impact can be vital for under-resourced communities, such Spanish-speaking Latinos. However, ASLA markers are understudied in this group and may differ from those established in widely studied populations (e.
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
Background: South Asian (SA) Americans are underrepresented in US Alzheimer's disease and related dementias (ADRD) research. Despite sharing common languages, SA Americans differ from those in South Asia in education, health-related behaviors, and environmental exposures. NYC/NJ-area SA communities overwhelmingly revealed English-based neuropsychological testing preference given that many speak non-Hindi languages.
View Article and Find Full Text PDFSexual health in women and sexual-gender-minority patients with cancer: A nationwide survey on healthcare professional awareness and attitude on behalf of MITO and AIRO-gynecology group.
J Cancer Policy
December 2024
Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy; Research Center for Reproductive Medicine, Gynecological Endocrinology and Menopause, Foundation IRCCS Polyclinic San Matteo, Pavia, Italy.
Background: Compared to male patients, sexual health remains poorly studied in women and sexual gender minority (SGM) patients with cancers.
Material And Methods: An online survey was developed by a multidisciplinary team to assess the awareness and attitude of Italian oncological providers facing sexual health during or after cancer treatment. On behalf of the respective scientific committees, the questionnaire was sent to Multicenter Italian Trials in Ovarian cancer and gynecologic malignancies group (MITO) and to Italian Association of Radiation Oncology (AIRO) Group.
Impervious cover change as an indicator of environmental equity.
Remote Sens Appl
August 2024
Texas State University, Department of Sociology, 601 University Dr., San Marcos, TX 78666.
Pattern-focused environmental equity research has been underpinned by high-resolution remotely sensed data to uncover spatial relationships between environmental amenities (e.g., urban tree cover) and socio-economic status (SES).
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