AI Article Synopsis
- * They found that low erythropoietin levels (≤3.3 mUI/ml) and JAK2 mutations had similar positive predictive values for identifying true polycythemia, around 90% for both tests.
- * Notably, very low erythropoietin levels (≤1.99 mUI/ml) were 100% predictive for diagnosing polycythemia vera, suggesting a need to rethink how erythropoietin is used in diagnostic criteria for this disease.
Article Abstract
We assessed the diagnostic performances of erythropoietin and JAK2 mutations in 1,090 patients with suspected polycythemia who were referred for red cell mass (RCM) measurement. In patients with a high haematocrit and/or haemoglobin level, a low erythropoietin level (<=3·3 mUI/ml) and JAK2 mutation showed comparable positive predictive value (PPV) for true polycythemia (RCM>=125%), 92·1% and 90% respectively. A very-low erythropoietin level (<=1·99 mUI/ml) had a PPV of 100% for polycythemia vera (PV) diagnosis. We confirmed the correlations between RCM, erythropoietin and JAK2 variant allelic frequency in PV patients. This study prompts the need to revisit the role of EPO in PV diagnostic criteria.
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| http://dx.doi.org/10.1111/bjh.17848 | DOI Listing |
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