Data sources Four electronic databases, namely PubMed, Scopus, Web of Science and the Cochrane Central Register of Controlled Trials, were searched from their inception to 16 July 2019. The OpenGrey database was also used to identify unpublished studies.Study selection Eligible study designs included randomised controlled trials, cohort studies, case-control studies and case series with a retrospective, cross-sectional or prospective design related to implant placement in patients with a history of anti-angiogenic or antiresorptive medications. Selection was conducted by two independent reviewers; however, if a consensus was not reached, a third reviewer was involved. Studies required a minimum of five patients with a history of antiresorptive or anti-angiogenic drug therapy before implant placement and strict criteria were used to ensure studies reported sufficient data items for discussion. Only full papers in the English language were included.Data extraction and synthesis A total of 6,073 papers were initially identified following removal of duplicates and 29 of these met the inclusion criteria for this systematic review. Twenty-eight reported on bisphosphonates which included five cohort studies, six case-control studies and 17 case series. A single case series reported on denosumab and no studies were identified reporting on selective oestrogen receptor modulators, calcitonin or anti-angiogenics. The quality of the included cohort and case-control studies were assessed by applying the modified Newcastle-Ottawa scale while the case series were assessed according to the Joanna Briggs Institute critical appraisal checklist. A score of <50% was considered to indicate low quality, 50-70% moderate quality and >75% high quality. A standardised Microsoft Excel spreadsheet was used to extract data from the studies which included study design, number of cases, implants and controls, patient characteristics (systemic diseases/age/gender/smoking status), drug history (type of drug, indication, administration route, intake before implant placement), whether patients were taking the drug at the time of implant placement and follow-up, reported outcome and parameters (implant loss, failure, success, survival and incidence of medication-related osteonecrosis of the jaw [MRONJ]). Where data was missing, estimations were calculated and a qualitative synthesis of all data was performed.Results No single study reported all the relevant data required by the authors and the overall level of quality was moderate. Regarding implant failure, patients with a history of bisphosphonates for osteoporosis are not at increased risk. However, insufficient data was available for those with a history of bisphosphonates for cancer, or any other antiresorptive or anti-angiogenic medications. Comparing this to MRONJ, patients with a history of bisphosphonate treatment are at risk of developing MRONJ following implant placement, while those with a history of denosumab for osteoporosis have a negligible risk. There was insufficient data available to assess the risk of MRONJ for those with a history of denosumab for cancer or other antiresorptive or anti-angiogenic medications.Conclusions Patients with a history of bisphosphonate treatment are at risk of MRONJ following implant placement while patients who take bisphosphonates for osteoporosis are not at increased risk of implant failure. There is a negligible risk of developing MRONJ in those taking denosumab for osteoporosis. However, practitioners should bear in mind a lack of high-quality evidence regarding the safety of placing implants in patients with a history of antiresorptive or anti-angiogenic medications.
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http://dx.doi.org/10.1038/s41432-021-0196-9 | DOI Listing |
J Clin Med
January 2025
Department of Orthopedics and Traumatology, Private Medicabil Hospital, 16140 Nilüfer/Bursa, Türkiye.
: Developmental dysplasia of the hip (DDH), defined by the malalignment of the femoral head and acetabulum, is a major precursor to coxarthrosis, posing substantial challenges during total hip arthroplasty (THA). Patients with coxarthrosis secondary to DDH often exhibit acetabular bone insufficiency, which makes challenging surgical reconstruction difficult. This study aimed to compare the radiologic and functional outcomes of robotically assisted and conventional manual THA techniques in patients with coxarthrosis secondary to Crowe type III-IV DDH.
View Article and Find Full Text PDFJ Clin Med
January 2025
Comprehensive Dentistry for Adults and Gerodontology, Faculty of Dentistry, University of Seville, 41009 Seville, Spain.
Transalveolar sinus floor elevation (TSFE) is a surgical technique for the placement of dental implants in patients with reduced height of the maxillary posterior alveolar bone. This study aims to demonstrate the clinical outcomes of TSFE using the minimal invasive sinus elevation (MISE) technique in partially and totally edentulous maxillary patients. This prospective clinical study followed STROBE guidelines.
View Article and Find Full Text PDFJ Clin Med
January 2025
Department of Plastic, Reconstructive and Aesthetic Surgery and Hand Surgery, Centre Hospitalier Universitaire Vaudois (CHUV), 1011 Lausanne, Switzerland.
: Combining autologous fat grafting with implant placement is meant to improve the quality of implant-based breast reconstruction. The present study explores the concept of multi-stage composite breast reconstruction with repeated sessions of autologous fat grafting to increase mastectomy flap thickness and provide better pre-pectoral implant coverage. : Twenty-five consecutive patients underwent bilateral multi-stage composite expander-to-implant breast reconstruction and reverse expansion from August 2020 to April 2024.
View Article and Find Full Text PDFMedicina (Kaunas)
January 2025
Department of Clinical Specialistic and Dental Sciences, Polytechnic University of Marche, Via Tronto, 10/A, 60126 Ancona, Italy.
Alveolar ridge resorption following tooth loss poses a significant challenge for successful dental implant placement. In cases of severe atrophy, bone augmentation is required to restore sufficient bone volume. This technical note outlines a detailed, stepwise surgical protocol for horizontal and vertical alveolar ridge augmentation using customized titanium mesh.
View Article and Find Full Text PDFAntibiotics (Basel)
January 2025
Department of Prosthodontics, Study of Dental Medicine, University of Split School of Medicine, 21000 Split, Croatia.
: This study aimed to explore antibiotic prescribing practices for dental implant placement in Croatia. : We conducted a cross-sectional questionnaire-based study including dentists in Croatia who perform dental implant therapy. The questionnaire assessed the dentists' age, working experience, education level, and whether they use antibiotics for dental implant placement, as well as the choice of antibiotics, timing, and reasons for antibiotics use.
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